以下信息为主动公开的研究生招生宣传信息
目录
李建明   更新日期: 2018年9月26日
李建明,男,汉族,1964年11月生,江苏常熟市人,群众,博士研究生学历,理学博士学位,教授,博导。
工作单位   林学与风景园林学院
邮箱地址  jmlumaa@scau.edu.cn
个人简介
李建明教授为华南农业大学林学与风景园林学院植物激素生物学研究团队负责人,主要从事植物固醇类激素-油菜素内酯信号转导及分子机制研究。在国际上首次报道了BR作为一种新型的植物激素为植物正常生长发育所必需,并对BR的生物合成和信号转导开展了系统而深入的研究,阐明了一条由蛋白质磷酸化介导的BR信号传递链。研究成果相继发表在Science、Cell、Mol Cell、PNAS和Plant Cell等顶尖期刊共计60余篇,被引用千次以上。目前主要利用BR受体突变体为遗传材料,开展了植物内质网蛋白质质量监控和相关降解机制研究,取得了许多国际领先的原创性研究成果,为深入理解植物生长发育、逆境胁迫和植物抗病机理奠定坚实的理论基础。
工作经历
1984-1988年:苏州第四制药厂的研发部门担任助理工程师
1995-1998年:美国的索克研究所从事植物分子遗传学的博士后的研究
1995-2011年:美国的密西根大学分子细胞及发育生物系先后担任助理教授,副教授,及终身正教授
2011-2017年:中国科学院上海生命科学研究院上海植物逆境生物学研究中心担任资深研究员,博士生导师,及中心副主任。
2017.12-至今:华南农业大学林学与风景园林学院,教授,博士生导师
教育经历
1980-1984年:南京大学生物系毕业,学士学位
1988-1990年:美国内布拉斯加林肯大学的生物化学系攻读硕士学位
1990-1995年:美国弗杰尼亚大学生物系学习,获博士学位
研究领域
主要从事植物固醇类激素-油菜素内酯信号转导及分子机制研究,在国际上首次报道了BR作为一种新型的植物激素为植物正常生长发育所必需,并对BR的生物合成和信号转导开展了系统而深入的研究。阐明了一条由蛋白质磷酸化介导的BR信号传递链。研究成果相继发表在Science、Cell、Mol Cell、PNAS和Plant Cell等顶尖期刊共计60余篇,被引用千次以上。
目前利用BR受体突变体为遗传材料,开展了植物内质网蛋白质质量监控和相关降解机制研究,并将以模式植物和南方重要经济林木为基础,开展植物激素生物学、蛋白质折叠与降解、林木生物技术改良等几个方面的工作。
科研项目
国家自然科学基金重点项目:植物内质网介导的蛋白质降解机制研究(),201801-202212,280万元
中国科学院战略先导项目(A类):水稻抗倒伏高产分子模块解析(XDA08010103),201701-201712,76万元
中国科学院上海生命科学研究院首席科学家项目:植物降解错误折叠蛋白的遗传及生化研究(2012CSP004),201301-201512, 300万元
发表论文
1. Li, J., P. Nagpal, V. Vitart, T. C. McMorris, and J. Chory (1996). A role for brassinosteroids in light-dependent development of Arabidopsis. Science 272, 398-401.
2. Chory, J., M. Chatterjee, R. K. Cook, T. Elich, C. Fankhauser, J. Li, P. Nagpal, M. Neff, A. Pepper, D. Poole, J. Reed, and V. Vitart (1996). From seed germination to flowering, light control plant development via the pigment phytochrome. Proc. Natl. Acad. Sci. USA 93, 12066-12071.
3. Fujioka, S., Y.-H. Choi, S. Takatsuto, T. Yokota, J. Li, J. Chory, and A. Sakurai (1996). Identification of castasterone, 6-deoxocastasterone, typhasterol and 6-deoxotyphasterol from the shoots of Arabidopsis thaliana. Plant Cell Physiol. 37, 1201-1203.
4. Li, J., Biswas, M. G., Chao, A., Russell, D. W., and J. Chory (1997). Conservation of function between mammalian and plant steroid 5a-reductases. Proc. Natl. Acad. Sci. USA 94, 3554-3559.
5. Chory, J. and J. Li (1997). Gibberllins, brassinosteroids and light-regulated development. Plant Cell and Environment 20, 801-806.
6. Li, J. and J. Chory (1997). A putative leucine-rich-repeat receptor kinase involved in brassinosteroid signaling pathway. Cell 90, 929-938.
7. Fujioka, S., J. Li, Y.-H., Choi, H. Seto, S. Takatsuto, T. Noguchi, T., Watanabe, H., Kuriyama, T. Yokata, J., Chory, and A. Sakurai (1997). The Arabidopsis de-etiolated2 mutant is blocked early in brassinosteroid biosynthesis. Plant Cell 9, 1951-1962.
8. Li, J. and J. Chory (1999). Steroid actions in plants. J. Exp. Botany, 50, 275-282.
9. Noguchi T, Fujioka S, Takatsuto S, Sakurai A, Yoshida S, Li J, Chory J. (1999). Arabidopsis det2 is defective in the conversion of (24R)-24-methylcholest-4-En-3-one to (24R)-24-methyl-5alpha-cholestan-3-one in brassinosteroid biosynthesis. Plant Physiol 120, 833-840.  
10. Streatfield SJ, Weber A, Kinsman EA, Hausler RE, Li J, Post-Beittenmiller D, Kaiser WM, Pyke KA, Flugge UI, Chory. J. (1999) The Phosphoenolpyruvate/Phosphate Translocator Is Required for Phenolic Metabolism, Palisade Cell Development, and Plastid-Dependent Nuclear Gene Expression. Plant Cell 11, 1609-1622.
11. He Z, Wang Z, J Li, Zhu Q, Lamb C, Ronald P, Chory J. (2000) Perception of brassinosteroids by the extracellular domain of the receptor kinase, BRI1. Science 288, 2360-2363.
12. Friedrichsen DM, Joazeiro CAP, Li J., Hunter T, and Chory J. (2000). Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. Plant Physiol. 123, 1247-1256.
13. Li J, Nam KH, Vafeados D, Chory J. (2001) BIN2, a new brassinosteroid-insensitive locus in Arabidopsis. Plant Physiol. 127, 14-22.
14. Li J, Nam KH. (2002) Regulation of brassinosteroid signaling by a GSK3/SHAGGY-like kinase. Science 295, 1299-1301.
15. Yin Y, Wang ZY, Mora-Garcia S, Li J, Yoshida S, Asami T, Chory J. (2002) BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation. Cell 109, 181-191.
16. Nam KH, Li J. (2002) BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling. Cell 110, 203-212.
17. He JX, Gendron JM, Yang Y, Li J, Wang ZY. (2002) The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis. Proc Natl Acad Sci U S A. 99, 10185-10190.
18. Zhao J, Peng P, Schmitz RJ, Decker AD, Tax FE, Li J. (2002) Two Putative BIN2 Substrates Are Nuclear Components of Brassinosteroid Signaling.  Plant Physiol. 130, 1221-1229.
19. Li J. (2003) Brassinosteroids. Encyclopedia of Hormones: Plant Hormones, Ed. P. B. Larsen, Academy Press, San Diego.
20. Li J. (2003). Brassinosteroids signal through two receptor-like kinases. Curr. Opin. Plant Biol. 6, 494-499.
21. Peng P, Li J (2003). Brassinosteroid signal transduction: a mix of conservation and novelty. J. Plant Growth Regul 22, 298-312.
22. Dievart A, Dalal M, Tax FE, Lacey AD, Huttly A, Li J, Clark SE. (2003). CLAVATA1 dominant-negative alleles reveal functional overlap between multiple receptor kinases that regulate meristem and organ development. Plant Cell 15,1198-1211.
23. Nam KH, Li J (2004). The Arabidopsis Transthyretin-Like Protein Is a Potential Substrate of BRASSINOSTEROID-INSENSITIVE 1. Plant Cell 16, 2406-2017.
24. Cano-Delgado A, Yin Y, Cong Y, Vafeados D, Mora-Garcia S, Cheng J-C, Nam KH, Li J*, Chory J*. (2004). BRL1 and BRL3 are novel brassinosteroid receptors that function in vascular differentiation in Arabidopsis. Development 131, 5341-5351 (* co-correspondence authors).
25. Li J (2005) Brassinosteroid signaling: from receptor kinases to transcription factors. Curr Opin Plant Biol. 8, 526-531.
26. Diévart A, Hymes MJ, Li J, Clark S (2006) Brassinosteroid-independent function of BRI1 / CLV1 chimeric receptors . Func. Plant Biol. 33, 723-730.
27. Li J, Jin H (2007) Regulation of brassinosteroid signaling. Trends Plant Sci. 12, 37-41.
28. Jin H, Yan Z, Nam KH, Li J (2007) Allele-specific suppression of a defective brassinosteroid receptor reveals an essential role of UDP-glucose:glycoprotein glucosyltransferase for a high-fidelity ER quality control. Mol. Cell 26, 821-830.
29. Peng P, Yan Z, Zhu Y, Li J (2008) Regulation of the Arabidopsis GSK3-like Kinase BRASSINOSTEROID-INSENSITIVE 2 through Proteasome-Mediated Protein Degradation. Mol Plant 1: 338-346.
30. Shan L., He P., Li J. , Heese A., Peck S. C., Nurnberger T., Martin G. B., and Sheen J. (2008). Bacterial Effectors Target the Common Signaling Partner BAK1 to Disrupt Multiple MAMP Receptor-Signaling Complexes and Impede Plant Immunity. Cell Host & Microbe 4, 17-27.
31. Hong Z, Jing H, Tzifira T, Li J (2008) Multiple mechanism-mediated retention of a defective brassinosteroid receptor in the endoplasmic reticulum. Plant Cell 20: 3418-3429.
32. Wang H, Zhu YY, Fujioka S, Asami T, Li JY, Li JM.(2009) Regulation of Arabidopsis brassinosteroid signaling by atypical basic helix-loop-helix proteins. Plant cell 21: 3781-3791
33. Jin H, Hong Z, Su W, Li JM(2009) A plant-specific calreticulin is a key retention factor for a defective brassinosteroid receptor in the endoplasmic reticulum. Proc Natl Acad Sci USA 106(32), 13612-13617
34. Hong Z, Jin H, Fitchette A, Xia Y, Monk A, Faye L, Li JM (2009) Mutations of an α 1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis. Plant Cell 21: 3792-3802
35. Yan Z, Zhao J, Peng P, Chihara R, Li J (2009) BIN2 functions redundantly with other GSK3-like kinases in regulating brassinosteroid signaling. Plant Physiology 150: 710-721
36. Peng P, Zhao J, Zhu,YY, Asami T,  Li J (2010) A direct docking mechanism for a plant GSK3 kinase to phosphorylate its substrates.The Journal of Biological chemistry 285(32): 24646-24653
37. Kang B, Wang H, Nam KH, Li JY, Li JM(2010) Activation-tagged suppressors of a weak brassinosteroid receptor mutant. Molecular Plant 3(1):260-268
38. Li JM(2010)Regulation of the nuclear activities of brassinostreroid signaling. Curr Opin Plant Biol 13(5): 540-547
39. Su W, Liu YD, Xia Y, Hong Z, Li JM(2011)Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Proc Natl Acad Sci USA 108(2): 870-875
40. Li JM(2011)Direct involvement of leucine-rich repeats in assembling ligand-triggered receptor-coreceptor complexes. Proc Natl Acad Sci USA 108(20): 8073-8074.
41. Su W, Liu YD, Xia Y, Hong Z, Li JM(2012) The arabidopsis homolog of the mammalian OS-9 protein plays a key role in the endoplasmic reticulum-associated degradation of misfolded receptor-like kinases. Molecular Plant 5(4): 929-940
42. Hong Z, Kajiura H, Su W, Jin H, Kimura A, Fujiyama K Li JM (2012) Evolutionarily conserved glycan signal to degrade aberrant brassinosteroid receptors in Arabidopsis. Proc Natl Acad Sci USA 109(28), 11437-11442.
43. Lin L, Zhong SH, Cui XF, Li JM, He ZH (2012) Characterization of temperature-sensitive mutants reveals a role for receptor-like kinase SCRAMBLED/STRUBBELIG in coordinating cell proliferation and differentiation during Arabidopsis leaf development. The Plant Journal 72: 707-720
44. Liu YD, Li JM(2013) An in vivo investigation of amino acid residues critical for the lectin function of Arabidopsis calreticulin 3. Molecular Plant 6(3): 985-987
45. Zhong SH, Liu JZ, Jin H, Lin L, Li Q, Chen Y, Yuan YX, Wang ZY, Huang H, Qi YQ, Chen XY, Vaucheret H, Chory J, Li JM, He ZH (2013) Warm temperatures induce transgenerational epigenetic release of RNA silencing by inhibiting siRNA biogenesis in Arabidopsis. Proc Natl Acad Sci USA 110(22): 9171-9176
46. Liu YD, Li JM(2014) Endoplasmic reticulum-mediated protein quality control in Arabidopsis. Frontiers in Plant Science 5: 1-11
47. Liu YD, Zhang CC, Wang DH, Su W, Liu LC, Wang MY, Li JM (2015). EBS7 is a plant-specific component of a highly conserved endoplasmic reticulum-associated degradation system in Arabidopsis. Proc Natl Acad Sci USA 112(39): 12205-12210
48. Shen H, Zhong XB, Zhao FF, Wang YM, Yan BX, Li Q, Chen GY, Mao BZ, Wang JJ, Li YS, Xiao GY, He YK, Xiao H, Li JM, He ZH (2015). Overexpression of receptor-like kinase ERECTA improves thermotolerance in rice and tomato. Nature Biotechnology 33(9): 996-1003
49. Zhang L, Yu H, Ma B, Liu GF, Wang JJ, Wang JM, Gao RC, Li JJ, Liu JY, Xu J, Zhang YY, Li Q, Huang XH, Jianlong Xu, Jianming Li, Qian Qian, Bin Han, Zuhua He, Jiayang Li (2017). A natural tandem array alleviates epigenetic repression of IPA1 and leads to superior yielding rice. Nature Communications 8: 14789
50. Liu CF, Niu GT , Zhang HC , Sun YF , Sun SB , Yu FG , Lu S , Yang YH , Li JM , Hong Z(2018). Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis. Molecular Plant 11(5): 678-690
我的团队
目前团队成员含教授1人,首聘教授1人,副研究员2人,讲师1人,承担国家自然科学基金重点项目、面上项目和青年项目等多个研究课题,科研经费充裕。实验室将以模式植物和南方重要经济林木为基础,开展植物激素生物学、蛋白质折叠与降解、林木生物技术改良等几个方面的工作。
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