以下信息为主动公开的研究生招生宣传信息
目录
张世海   更新日期: 2023年1月28日
张世海,男,汉族,1989年1月生,福建建瓯市人,群众,博士研究生学历,农学博士学位,副教授,硕导。
工作单位   华南农业大学
通讯地址  华南农业大学新动科大楼505
邮箱地址  zhangshihai@scau.edu.cn
个人简介
张世海,中国农业大学和北卡罗莱纳州立大学联合培养博士。现为华南农业大学动物科学学院副教授,硕士研究生导师,美国德州大学西南医学中心客座副教授。主要研究方向包括母仔猪营养、脂肪酸营养、氨基酸营养等。主讲《动物营养学》、《饲料学》等专业课课程。近年来,以第一或通讯作者在PloS Genetics,Nutrition Research Reviews等国内外权威期刊发表SCI论文45篇,其中TOP期刊10篇,论文总引用次数达2300余次。先后主持/参与国家自然科学基金,十四五国家重点研发计划青年科学家项目课题,十三五国家重点研发计划重点专项子课题,广东省自然科学基金,广州市科技计划等。入选华南农业大学“卓越青年教师百人计划”,曾获华南农业大学动物科学学院“青年教师教学观摩比赛”一等奖、华南农业大学“青年教师教学优秀奖”一等奖、华南农业大学“本科课堂教学十佳教师”,在广东省第六届高校(本科)青年教师教学大赛中获工科组一等奖(冠军)。Email: zhangshihai@scau.edu.cn
工作经历
2016-2019:华南农业大学,动物科学,首聘副教授
2020-       :华南农业大学,动物科学,副教授
2019-2020: 美国德州大学西南医学中心,分子生物学,客座副教授
教育经历
2014-2015:North Carolina State University,动物科学,联合培养博士
2011-2016:中国农业大学,动物营养与饲料科学,博士
2007-2011:中国农业大学,动物科学,学士
获奖荣誉
2018年 华南农业大学 “青年教师教学优秀奖” 一等奖
2018年 华南农业大学 动物科学学院 “教学十佳”
2019年 华南农业大学 动物科学学院“青年教师成长奖”
2021年 华南农业大学 动物科学学院“青教赛一等奖”
2021年 华南农业大学 动物科学学院“青年教师成长奖”
2022年 华南农业大学 “教学十佳”
2022年 广东省第六届高校(本科)青年教师教学大赛工科组一等奖(冠军)
2022年 华南农业大学 卓越青年教师百人计划
社会、学会及学术兼职
中国高科技产业化研究会饲料分会理事
Frontiers in Cell and Developmental Biology (SCI收录)期刊 Review Editor
Antioxidants (SCI收录)期刊 Guest Editor
Frontiers in Sustainable Food Systems (SCI收录)期刊 Guest Associate Editor
Agriculture(SCI收录)期刊 Guest Editor
研究领域
主要研究方向包括母仔猪营养、氨基酸营养、仔猪肠道健康与功能等
科研项目
主要主持项目
1. 肠道氨基酸感知受体介导支链氨基酸调控仔猪采食量的机制研(31802067) ,国家科学自然基金委, 2019.1-2021.12
2. 肠道和大脑氨基酸感知受体介导支链氨基酸调控仔猪采食量的机制研究 (2018A030310201) 广东省自然科学基金,2018.5.1-2021.4.30
3. 胃肠道氨基酸感知受体影响仔猪采食量的作用机制,华南农业大学青年科技人才培育专项基金, 2017.1-2018.12
4. 饲粮中添加OxC-beta和硒对母猪繁殖性能的影响及其机制(2018YFD0500600),国家重点研发计划2018.6-2021.6
5. FFAR2对母猪泌乳功能的调节作用及其机制研究 (202102020056), 广州市科技计划2021.4.1-2023.3.31
6. GPR43介导Gα信号通路调控母猪泌乳功能的机制研究 (2021A1515010440),广东省自然科学基金, 2021.01-2023.12
7.GPR120介导油酸调节母猪乳脂合成的机制研究,广东省自然科学基金,2023.01-2025.12


主要参与项目
1. 母猪泌乳能力及初乳IgA含量提升的营养调控机制, 国家重点研发计划青年科学家项目(2021YFD1300700), 2021.12-2026.11
2. 长链脂肪酸调节母猪乳脂合成的分子机制(31872364),国家科学自然基金,2019.1-2022.12
3. 不同种类和加工工艺的油脂对肠道稳态和肠道微生物菌群定植的影响(2017YFD0500501),国家重点研发计划项目, 2017.9-2020.12
发表论文
44. Li, L., Wu, W., Deng, Z., Zhang, S.*, & Guan, W*. (2022). Improved thermostability of lipase Lip2 from Yarrowia lipolytica through disulfide bond design for preparation of medium-long-medium structured lipids. LWT, 166, 113786. (*通讯作者,IF 2021=6.1, 2022中科院分区一区)
43. Zhang, S., Xiong, L., Cui, C., Zhao, H., Zhang, Y., Tian, Z., Guan, W.*, & Chen, F*. (2022). Maternal supplementation with Artemisia annua L. ameliorates intestinal inflammation via inhibiting the TLR4/NF-κB and MAPK pathways and improves the oxidative stability of offspring. Food & function, 13(18), 9311–9323. (第一作者,IF 2021=6.3,2022中科院分区一区)
42. Cui, C., Wu, C., Wang, J., Zheng, X., Ma, Z., Zhu, P., Guan, W., Zhang, S.*, & Chen, F. *(2022). Leucine supplementation during late gestation globally alters placental metabolism and nutrient transport via modulation of the PI3K/AKT/mTOR signaling pathway in sows. Food & function, 13(4), 2083–2097. (*通讯作者,IF 2021=6.3,2022中科院分区一区)
41. Xiong, L., Zhang, W., Zhao, H., Tian, Z., Ren, M., Chen, F., Guan, W.*, & Zhang, S*. (2022). Dietary Supplementation of Enzymatically Treated Artemisia annua L. Improves Lactation Performance, Alleviates Inflammatory Response of Sows Reared Under Heat Stress, and Promotes Gut Development in Preweaning Offspring. Frontiers in veterinary science, 9, 843673. (*通讯作者,IF 2021=3.4, 2022中科院分区二区)
40. Tian, M., Li, L., Tian, Z., Zhao, H., Chen, F., Guan, W., & Zhang, S. (2022). Glyceryl butyrate attenuates enterotoxigenic Escherichia coli-induced intestinal inflammation in piglets by inhibiting the NF-κB/MAPK pathways and modulating the gut microbiota. Food & function, 13(11), 6282–6292. (*通讯作者,IF 2021=6.3, 2022中科院分区一区)
39. Wu, Z., Li, Q., Yang, S., Zheng, T., Shao, J., Guan, W., Chen, F., & Zhang, S. (2022). Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α. Cell communication and signaling, 20(1), 25. (*通讯作者,IF 2021=7.5,2022中科院分区二区)
38. Wu, Z., Xu, C., Zheng, T., Li, Q., Yang, S., Shao, J., Guan, W., & Zhang, S. (2022). A critical role of AMP-activated protein kinase in regulating intestinal nutrient absorption, barrier function, and intestinal diseases. Journal of cellular physiology, 237(10), 3705–3716. (*通讯作者,IF 2021=6.5,2022中科院分区二区)
37. Li, Q., Yang, S., Zhang, X., Liu, X., Wu, Z., Qi, Y., Guan, W., Ren, M., & Zhang, S. (2022). Maternal Nutrition During Late Gestation and Lactation: Association With Immunity and the Inflammatory Response in the Offspring. Frontiers in immunology, 12, 758525. (*通讯作者,IF 2021=8.7,2022中科院分区二区)
36. Tian, M., Wu, Z., Heng, J., Chen, F., Guan, W.,* & Zhang, S.* (2022). Novel advances in understanding fatty acid–binding G protein–coupled receptors and their roles in controlling energy balance. Nutrition Reviews, 2022;80(2):187-199. (*通讯作者,IF 2020=7.1,2022中科院分区二区)
34. Li, Q., Yang, S., Chen, F., Guan, W.*, & Zhang, S*. (2022). Nutritional strategies to alleviate oxidative stress in sows. Animal Nutrition. 9, 60–73. (*通讯作者,IF 2021=6.3,2022中科院分区一区)
35. Zhang, S., Wang, H., Melick, C. H., Jeong, M. H., Curukovic, A., Tiwary, S., ... & Jewell, J. L. (2021). AKAP13 couples GPCR signaling to mTORC1 inhibition. PLoS Genetics, 17(10), e1009832.(第一作者,IF 2020=5.9,自然指数期刊)
33. Qi, Y., Zhang, X., Wu, Z., Tian, M., Chen, F., Guan, W., & Zhang, S. (2022). Ferroptosis Regulation by Nutrient Signalling. Nutrition research reviews, 35(2), 282–294.  (*通讯作者,IF 2021=8.1,2021中科院分区二区)
Zhang, W., Xiong, L., Chen, J., Tian, Z., Liu, J., Chen, F., Guan, W.* & Zhang, S*. (2021). Artemisinin Protects Porcine Mammary Epithelial Cells against Lipopolysaccharide-Induced Inflammatory Injury by Regulating the NF-κB and MAPK Signaling Pathways. Animals, 11(6), 1528.(*通讯作者,IF 2020=2.8)
32. Song, H., Chai, W., Yang, F., Ren, M., Chen, F., Guan, W.,* & Zhang, S.* (2021). Effects of Dietary Monoglyceride and Diglyceride Supplementation on the Performance, Milk Composition, and Immune Status of Sows During Late Gestation and Lactation. Frontiers in Veterinary Science, 8. (*通讯作者,IF 2020=3.4)
31. Yi, Q., Liu, J., Zhang, Y., Qiao, H., Chen, F., Zhang, S.,* & Guan, W*. (2021). Anethole attenuates enterotoxigenic Escherichia coli-induced intestinal barrier disruption and intestinal inflammation via modification of TLR signaling and intestinal microbiota. Frontiers in microbiology, 12. (*通讯作者,IF 2020=5.6)
30. Tian M, Chen J, Wu Z, Chen, F., Zhang, S.,* & Guan, W*. Fat encapsulation reduces diarrhea in piglets partially by repairing the intestinal barrier and improving fatty acid transport[J]. Animals, 2021, 11(1): 28. (*通讯作者,IF 2020=2.8)
29. Zhang, W. F., Tian, M., Song, J. S., Chen, F., Lin, G., Zhang, S. H.*, & Guan, W. T*. (2021). Effect of replacing inorganic trace minerals at lower organic levels on growth performance, blood parameters, antioxidant status, immune indexes, and fecal mineral excretion in weaned piglets. Tropical Animal Health and Production, 53(1), 1-8. (IF: 2.7) (*通讯作者,IF 2020=1.6)
28.Wu, Z., Heng, J., Tian, M., Song, H., Chen, F., Guan, W*., & Zhang, S*. (2020). Amino acid transportation, sensing and signal transduction in the mammary gland: key molecular signalling pathways in the regulation of milk synthesis. Nutrition research reviews, 33(2), 287–297. (*通讯作者,IF 2019 = 7.641,2020中科院分区一区)
27. Heng, J., Wu, Z., Tian, M., Chen, J., Song, H., Chen, F., Guan, W*., & Zhang, S*. (2020). Excessive BCAA regulates fat metabolism partially through the modification of m6A RNA methylation in weanling piglets. Nutrition & metabolism, 17, 10. (*通讯作者,IF 2019 =3.211)
26. Zhang, W., Heng, J., Kim, S.W., Chen, F., Deng, Z., Zhang, S*, Guan, W*. Dietary enzymatically-treated Artemisia annua L. supplementation could alleviate oxidative injury and improve reproductive performance of sows reared under high ambient temperature[J]. Journal of Thermal Biology, 2020, 94: 102751. (*通讯作者,IF 2019=2.361)
25. Tian, M., Chen, J., Liu, J., Chen, F., Guan, W*, Zhang, S*, Dietary fiber and microbiota interaction regulates sow metabolism and reproductive performance[J]. Animal Nutrition, 2020. (*通讯作者, IF 2019=4.492,2020中科院分区一区)
24. Tian, M., Qi, Y., Zhang, X., Wu, Z., Chen, J., Chen, F., Guan, W*, Zhang, S*. Regulation of the JAK2-STAT5 pathway by signaling molecules in the mammary gland[J]. Frontiers in Cell and Developmental Biology, 2020, 8: 1382. (*通讯作者, IF 2019=5.201)
23. Wu, Z., Tian, M., Heng, J., Chen, J., Chen, F., Guan, W*., & Zhang, S*. (2020). Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology. Frontiers in cell and developmental biology, 8, 530. (*通讯作者,  IF 2019=5.201)
22. Ren, C., Wang, Y., Lin, X., Song, H., Zhou, Q., Xu, W., Shi, K., Chen, J., Song, J., Chen, F., Zhang, S.*, & Guan, W*. (2020). A Combination of Formic Acid and Monolaurin Attenuates Enterotoxigenic Escherichia coli Induced Intestinal Inflammation in Piglets by Inhibiting the NF-κB/MAPK Pathways with Modulation of Gut Microbiota. Journal of agricultural and food chemistry, 68(14), 4155–4165. (*通讯作者,  IF 2019=4.192,2020中科院分区一区)
21. Zhang, S., Wu, Z., Heng, J., Song, H., Tian, M., Chen, F., & Guan, W*. (2020). Combined yeast culture and organic selenium supplementation during late gestation and lactation improve preweaning piglet performance by enhancing the antioxidant capacity and milk content in nutrient-restricted sows. Animal nutrition, 6(2), 160–167. (第一作者,IF 2019=4.492,2020中科院分区一区)
20. Yang, F.#, Zhang, S.#, Tian, M., Chen, J., Chen, F., & Guan, W*. (2020). Different Sources of High Fat Diet Induces Marked Changes in Gut Microbiota of Nursery Pigs. Frontiers in microbiology, 11, 859. (#第一作者,IF 2019=4.235)
19. Zhang, S., Wu, Z., Heng, J., Tian, M., Chen, J., Chen, F., & Guan, W*. (2020). L-carnitine increases cell proliferation and amino acid transporter expression via the activation of insulin-like growth factor I signaling pathway in rat trophoblast cells. Food science & nutrition, 8(7), 3298–3307. (第一作者, IF 2019=1.797)
18. Heng, J., Tian, M., Zhang, W., Chen, F., Guan, W.*, & Zhang, S*. (2019). Maternal heat stress regulates the early fat deposition partly through modification of m6A RNA methylation in neonatal piglets. Cell stress & chaperones, 24(3), 635–645. (*通讯作者, IF 2019=2.892)
17. Tian, M., Heng, J., Song, H., Shi, K., Lin, X., Chen, F., Guan, W., & Zhang, S*. (2019). Dietary Branched-Chain Amino Acids Regulate Food Intake Partly through Intestinal and Hypothalamic Amino Acid Receptors in Piglets. Journal of agricultural and food chemistry, 67(24), 6809–6818. (*通讯作者, IF 2019=4.192,2019中科院分区一区)
16. Tian, M., Heng, J., Song, H., Zhang, Y., Chen, F., Guan, W., & Zhang, S*. (2019). Branched chain amino acids stimulate gut satiety hormone cholecystokinin secretion through activation of the umami taste receptor T1R1/T1R3 using an in vitro porcine jejunum model. Food & function, 10(6), 3356–3367. (*通讯作者, IF 2019=4.171,2019中科院分区一区)
15. Li, L.#, Zhang, S.#, Wu, W., Guan, W., Deng, Z., & Qiao, H. (2019). Enhancing thermostability of Yarrowia lipolytica lipase 2 through engineering multiple disulfide bonds and mitigating reduced lipase production associated with disulfide bonds. Enzyme and microbial technology, 126, 41-49. (#第一作者,  IF 2019=3.448)
14. Zhang, S., Heng, J., Song, H., Zhang, Y., Lin, X., Tian, M., Chen, F., & Guan, W. (2019). Role of Maternal Dietary Protein and Amino Acids on Fetal Programming, Early Neonatal Development, and Lactation in Swine. Animals : an open access journal from MDPI, 9(1), 19. (第一作者, IF 2019=2.323)
13. Zhang, S., Chen, F., Zhang, Y., Lv, Y., Heng, J., Min, T., Li, L., & Guan, W. (2018). Recent progress of porcine milk components and mammary gland function. Journal of animal science and biotechnology, 9, 77. (第一作者,  IF 2018=3.441,中科院分区2020一区)
12. Zhang, S., Tian, M., Song, H., Shi, K., Wang, Y., & Guan, W. (2018). Effects of L-carnitine on reproductive performance, milk composition, placental development and IGF concentrations in blood plasma and placental chorions in sows. Archives of animal nutrition, 1-14. (第一作者,  IF 2018=1.786)
11. Zhang, S., Zhang, X., Qiao, H., Chen, J., Fang, C., Deng, Z., & Guan, W. (2018). Effect of timing of post-weaning supplementation of soybean oil and exogenous lipase on growth performance, blood biochemical profiles, intestinal morphology and caecal microbial composition in weaning pigs. Italian Journal of Animal Science, 1-9. (第一作者, IF 2018=1.265)
10. Zhang, Y.#, Zhang, S.#, Guan, W., Chen, F., Cheng, L., Lv, Y., & Chen, J. (2018). GLUT1 and lactose synthetase are critical genes for lactose synthesis in lactating sows. Nutrition & metabolism, 15, 40. (#第一作者, IF 2018=3.599)
9. Yang, F.#, Zhang, S.#, Kim, S. W., Ren, C., Tian, M., Cheng, L., Song, J., Chen, J., Chen, F., & Guan, W. (2018). Fat encapsulation enhances dietary nutrients utilization and growth performance of nursery pigs. Journal of animal science, 96(8), 3337–3347. (#第一作者, IF 2018=1.697)
8. Zhang, S., Song, J., Deng, Z., Cheng, L., Tian, M., & Guan, W. (2017). Effects of combined α-galactosidase and xylanase supplementation on nutrient digestibility and growth performance in growing pigs. Archives of animal nutrition, 71(6), 441-454. (第一作者, IF 2017=1.887)
7. Zhang, S., Zeng, X., Ren, M., Mao, X., & Qiao, S. (2017). Novel metabolic and physiological functions of branched chain amino acids: a review. Journal of animal science and biotechnology, 8, 10. (第一作者, IF 2017=3.205)
6. Zhang, S., Chu, L., Qiao, S., Mao, X., & Zeng, X. (2016). Effects of dietary leucine supplementation in low crude protein diets on performance, nitrogen balance, whole-body protein turnover, carcass characteristics and meat quality of finishing pigs. Animal science journal = Nihon chikusan Gakkaiho, 87(7), 911–920. (第一作者, IF 2016=1.325)
5. Ren, M.#, Zhang, S.#, Liu, X., Li, S., Mao, X., Zeng, X., & Qiao, S. (2016). Different Lipopolysaccharide Branched-Chain Amino Acids Modulate Porcine Intestinal Endogenous β-Defensin Expression through the Sirt1/ERK/90RSK Pathway. Journal of agricultural and food chemistry, 64(17), 3371–3379. (#第一作者, IF 2016=3.154)
4. Zhang, S., Yang, Q., Ren, M., Qiao, S., He, P., Li, D., & Zeng, X. (2016). Effects of isoleucine on glucose uptake through the enhancement of muscular membrane concentrations of GLUT1 and GLUT4 and intestinal membrane concentrations of Na+/glucose co-transporter 1 (SGLT-1) and GLUT2. The British journal of nutrition, 116(4), 593–602. (第一作者)
3. Ma, W. F.#, Zhang, S. H.#, Zeng, X. F., Liu, X. T., Xie, C. Y., Zhang, G. J., & Qiao, S. Y. (2015). The appropriate standardized ileal digestible tryptophan to lysine ratio improves pig performance and regulates hormones and muscular amino acid transporters in late finishing gilts fed low-protein diets. Journal of animal science, 93(3), 1052–1060.(#第一作者, IF 2015=2.014)
2. Zhang, S., Ren, M., Zeng, X., He, P., Ma, X., & Qiao, S. (2014). Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2) through PI3K/Akt/mTOR and ERK signaling pathways. Amino acids, 46(12), 2633–2642. (第一作者)
1. Zhang, S., Qiao, S., Ren, M., Zeng, X., Ma, X., Wu, Z., Thacker, P., & Wu, G. (2013). Supplementation with branched-chain amino acids to a low-protein diet regulates intestinal expression of amino acid and peptide transporters in weanling pigs. Amino acids, 45(5), 1191–1205. (第一作者)

第一作者或通讯作者发表中文文章:
[1] 恒景会,田敏,管武太,张世海(*).氧化应激对母畜乳腺功能的影响及其营养调控策略[J/OL].动物营养学报:2020,33( 1):1-9.
[2] 张宇峰,田敏,恒景会,陈芳,邓跃林,管武太(*),张世海(*).支链氨基酸对断奶仔猪肠道和肌肉氨基酸转运载体表达的影响[J].中国畜牧杂志,2020,56(04):92-99.
[3] 田敏,恒景会,张文飞,陈芳,邓跃林,管武太,张世海(*). 饲粮营养素调控母猪泌乳性能的研究进展.中国畜牧杂志,2018;(10):9-14.
科研创新
管武太,邓子潇,李力浪,吴炜坤,张世海. 一种耐热突变脂肪酶及制备方法与应用. 申请号:201711220144.8
管武太,李力浪,吴炜坤,邓子潇,张世海. 一种能提高耐热脂肪酶产量的重组工程菌及其构建方法和应用. 申请号:201711220171.5
管武太, 张世海,陈芳,桂干北,乔汉祯,谌俊. 一种改善母猪繁殖性能和抗氧化能力的组合物及其应用. 申请号: 201710361392.8
教学活动
本科生课程:《动物营养学》、《饲料学》、《饲料学综合实习》
研究生课程:《猪营养研究专题》
指导学生
指导研究生10名,合作指导研究生25名

优秀学生代表:
2018级 恒景会(国家奖学金)
2019级 吴志辉(国家奖学金、优秀毕业生)
2021级 李其晖(国家奖学金)
我的团队
管武太教授 母仔猪营养团队。 本团队包括教授1名,副教授3名。
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