目录
2010.8-2016.2 中科院上海生命科学研究院植物生理生态研究所，副研究员；
2016.2-现在 华南农业大学动物科学学院，教授。
2003.9-2008.6 南京林业大学森林资源与环境学院 博士。
2021年获得广东省自然科学奖一等奖（排名第三）；
2024年广东省蚕学会“科技创新奖”。
2023年中国昆虫学会发育与遗传专业委员会委员
2022年广东省畜禽遗传资源委员会专业委员会委员
2024年广东省昆虫学会资源昆虫学专业委员委员
2024年广东省蚕学会理事
2024年广东省遗传学会第十届理事会监事
以家蚕等昆虫变态发育及其与响应病原微生物的互作研究模型，解析其中发生的细胞死亡新机制，尤其是尚未在昆虫中研究报道的细胞死亡形式及其翻译后修饰调控机制益虫利用和害虫防治提供靶标位点。此外，还筛选与查找了高效抑制病原增殖的药物、化合物，详细分析了它们的作用机制，为畜禽疾病的治疗和生产保健提供理论指导。
（2）以家蚕、黑水虻等为对象，解析昆虫发育和免疫应答的表观修饰调控机制
着重解析幼虫-蛹变态发育中家蚕、果蝇幼虫组织重塑、家蚕不同品种对BmNPV抗性差异的形及肠道有益菌对黑水虻生长发育调控的表观修饰调控机制，详细分析了它们的作用靶点及通路，为畜禽疾病的治疗和生产保健提供理论指导。
（3）黑水虻等资源（蛋白）昆虫的基础生物学研究、种质开发及利用技术
团队长期从事黑水虻等腐生资源昆虫生长发育调控、种质资源收集与保护以及特殊性能品种培育和应用技术研发等工作，并利用遗传操作技术开展相关分子育种。
1. 国家自然科学基金面上项目：“跨膜蛋白在家蚕溶酶体驱动的细胞死亡中的分子作用机制”，2026/01-2029/12。
2. 广东省自然科学基金面上项目：“家蚕脂肪体溶酶体蛋白的鉴定与功能分析”, 2024/01- 2026/12。
3. 广东省自然科学基金面上项目：“细胞坏死在家蚕杆状病毒BmNPV增殖与传播中的作用机制”, 2022/01- 2024/12。
4. 国家自然科学基金面上项目：“蜕皮激素调控去乙酰酶Rpd3参与细胞自噬的分子机制”，2020/01-2023/12。
5. 国家自然科学基金面上项目：“家蚕自噬蛋白ATG1/ATG13和ATG3/ATG8翻译后的修饰作用”，2017/01-2020/12。
6. 国家自然科学基金面上项目：“细胞自噬对昆虫脂肪体中脂肪和储存蛋白的代谢调控”，2015.01-2018.1。
7. 广东省自然科学基金重点项目，基于果蝇细胞免疫性自噬的畜禽疫病中介研究模型的筛选，2017/05-2020/05。
2. Peng Zeng, Xiaodong Li, Xuan Jin, Qien Zhong, Fareed Uddin Memon, Youliang Pan, Yang Xiao, Kang Li*, Ling Tian*. Lysosomal acid lipase-1 functions in autophagy occurrence and lipid homeostasis dependent of heat shock protein 83 in insects. Insect Biochemistry and Molecular Biology, 186: 104447.
3. Fareed Uddin Memon, Yanqing Zhu, Ying Cui, Xingbao Feng, Sheraz Ahmad, Peng Zeng, Farhan Nabi, Dengjian Hao, Zhijun Huang, Gianluca Tettamanti, Ling Tian*. Gut microbial communities and transcriptional profiles of black soldier fly (Hermetia illucens) larvae fed on fermented sericulture waste Fareed. Waste Manag, 2025, 15:194:158-168.
4. Fareed Uddin Memon†, ChiHo Li†, Sheraz Ahmad, Ying Cui, Xingbao Feng, Peng Zeng, Farhan Nabi, Zhijun Huang, Gianluca Tettamanti, Ting Chen*, Ling Tian*. Efficiency of microbial fermentation on microbial shifts, enzymatic activity, and transcriptions in black soldier fly larvae during the sugarcane waste conversion. Environ Pollut, 2025, 15:381:126588.
5. Shihui Long, Yongyu Qiu, Tong Lin, Shumin Huang, Wenhao Zhang, Suning Liu, Ling Tian, Subba R Palli, Sheng Li, Kang Li. 20E-induced Kr-h1 expression facilitates developmental transitions depending on chromosome accessibility of BR-C enhancers. Proc Natl Acad Sci U S A, 2025, 122(32):e2509608122.
6. Ling Tian†, Qien Zhong†, Yubei Yang†, Wenmei Wu, Yang Xiao, Sheng Li*, Kang Li*. Lipid metabolites affected by deficient autophagy antagonize the occurrence of autophagy through AMPK signaling in insects. BMC Biol, 2025, 23(1):193.
7. Jiasheng Pan, Xiaodong Li, Rongsong Li, Yin Chen, Fareed Uddin Memon, Kun Wu, Jianghao Hu, Xiaole Xie, Jianhao Deng, Rongting Xu, Kang Li, Chuanxi Zhang, Ling Tian*. Baculovirus protein kinase 1 activates AMPK-protein phosphatase 5 axis to hijack transcription factor EB for self-proliferation. Int J Biol Macromol, 2025, 298:139884.
8. Sheraz Ahmad, Fareed Uddin Memon, Jiping Liu*, Ling Tian*. Insights into mulberry (Morus spp.) defense responses to Glyphodes pyloalis: a review of recent advances. International Journal of Pest Management, 2025, https://doi.org/10.1080/09670874.2025.2561626.
9. Liujuan Chen, Yangsheng Zhong, Guoxiang Qiu, Jianrong Lin, Jingyu Zhang, Huichao Yan, Shizhang Hong, Mingke Han, Fareed Uddin Memon*, Ling Tian*, Wenchu Li*. Changes in Saccharide Content and the Role of the PI3K-Akt Signal Transduction Pathway in Silkworm Eggs Treated with HCL to Prevent or Break Diapause. Arch Insect Biochem Physiol, 2025, 119(3):e70081.
10. Xingbao Feng, Zhijn Huang, Sheraz Ahmad, Chong Ma, Jianfeng Zhu, Kang Li, Guoliang Peng, Gianluca Tettamanti, Wengfeng Hu*, Hanhong Xu*, Ling Tian*. Selective breeding of heat-tolerant black soldier fly (Hermetia illucens) larvae: gut microbial shifts and transcriptional patterns. Journal of Insects as Food and Feed, 2025, https://doi.org/10.1163/23524588-00001439.
11. Feifei Chen, Guoxiang Qiu, Jingchen Sun, Huichao Yan, Shizhang Feng, Hanbo Li, Yangsheng Zhong, Mingke Han, Jiangrong Lin, Fareed Uddin Memon, Ling Tian*, Wenchu Li*. Expression Variations of Chloride Ion Channel Related Genes During Diapause Termination in Silkworm, Bombyx mori. Arch Insect Biochem Physiol, 2024, 117(4):e70019.
12. Xingbao Feng, Fareed Uddin Memon, Chong Ma, Jianfeng Zhu, Zhijun Huang, Gianluca Tettamanti, Kang Li, Gao Peng, Wenfeng Hu, Ling Tian*. Proteomic and transcriptomic analysis of cold- and heat-tolerant black soldier fly (Hermetia illucens) larvae. Journal of Insects as Food and Feed, 2024, 11 (3): 543-561.
13. Chong Ma, Zhijun Huang, Xingbao Feng, Fareed Uddin Memon, Ying Cui, Xinyu Duan, Jianfeng Zhu, Gianluca Tettamanti, Wenfeng Hu, Ling Tian*. Selective breeding of cold-tolerant black soldier fly (Hermetia illucens) larvae: Gut microbial shifts and transcriptional patterns. Waste Management, 2024, 1:177:252-265.
14. Haigang Zhao, Shihui Long, Suning Liu, Dongwei Yuan, Danyan Huang, Jing Xu, Qiuqin Ma, Guirong Wang, Jian Wang, Sheng Li, Ling Tian*, Kang Li*. Atg1 phosphorylation is activated by AMPK and indispensable for autophagy induction in insects. Insect Biochem Mol Biol, 2023 Jan:152:103888.
15. Qiuqin Ma, Jianhao Deng, Hanbo Li, Zhijun Huang*, Ling Tian*. Cytoskeleton protein BmACT1 is potential for the autophagic function and nuclear localization of BmAtg4b in Bombyx mori. Cells, 2023, 12(6):899.
16. Rongsong Li, Yang Xiao, Kang Li, Ling Tian*. Transcription and Post-translational Regulation of Autophagy in Insects. Front Physiol, 2022, 13:825202.
17. Jing Xu, Xiaole Xie, Qiuqin Ma, Lu Zhang, Yu Li, Yin Chen, Kang Li, Yang Xiao, Gianluca Tettamanti, Hanhong Xu*, Ling Tian*. Identification of Host Molecules Involved in the Proliferation of Nucleopolyhedrovirus in Bombyx mori. J Agric Food Chem. 2022, 70(45):14427-14438.
18. Qiuqin Ma, Shihui Long, Zhending Gan, Gianluca Tettamanti, Kang Li*, Ling Tian*. Transcriptional and Post-Transcriptional Regulation of Autophagy. Cells, 2022, 11(3):441.
19. Wenmei Wu, Man Luo, Kang Li, Yichen Dai, Huiyu Yi, Yangjin Zhong, Yang Cao, Gianluca Tettamanti, Ling Tian*. Cholesterol derivatives induce dephosphorylation of the histone deacetylases Rpd3/HDAC1 to upregulate autophagy. Autophagy, 2021, 17(2):512-528.
20. Wenmei Wu, Kang Li, Haigang Zhao, Xianying Xu, Jing Xu, Man Luo, Yang Xiao, Ling Tian*. Correction: Wu, W., et al. Tip60 Phosphorylation at Ser 99 Is Essential for Autophagy Induction in Bombyx mori. Int. J. Mol. Sci. 2020, 21, 6893. Int J Mol Sci, 2021, 22(4):1751.
21. Wenmei Wu, Kang Li, Sanyou Guo, Jing Xu, Qiuqin Ma, Shuyan Li, Xianying Xu, Zhijun Huang, Yangjin Zhong, Gianluca Tettamanti, Yang Cao, Sheng Li, Ling Tian*. P300/HDAC1 regulates the acetylation/deacetylation and autophagic activities of LC3/Atg8-PE ubiquitin-like system. Cell Death Discov, 2021, 7(1):128.
22. Yichen Dai, Kang Li, Wenmei Wu, Kunzhong Wu, Huiyu Yi, Wangyu Li, Yang Xiao, Yangjin Zhong, Yang Cao, Ling Tian*. Steroid hormone 20-hydroxyecdysone induces the transcription and complex assembly of V-ATPases to facilitate autophagy in Bombyx mori. Insect Biochem mole Biol, 2020, 116:103255.
23. Wenmei Wu, Kang Li, Haigang Zhao, Xianying Xu, Jing Xu, Man Luo, Yang Xiao, Ling Tian*. Tip60 Phosphorylation at Ser 99 Is Essential for Autophagy Induction in Bombyx mori. Inter J Mol Sci, 2020, 21(18):6893.
24. Shuyan Li, Jing Xu, Xianying Xu, Weiyuan Ma, Ling Tian*, Kang Li*. Functional identification of Bombyx mori Atg13 in autophagy. Arch Insect Biochem & Physiol, 2020, 105(1):e21718.
25. Yujie Wang, Shuyan Li, Jiaye Zhao, Kang Li, Jing Xu, Xian-Ying Xu, Wenmei Wu, Rong Yang, Yang Xiao, Ming-Qiang Ye, Jiping Liu, Yangjin Zhong, Yang Cao, Huiyu Yi*, Ling Tian*. Clathrin-dependent endocytosis predominantly mediates protein absorption by fat body from the hemolymph in Bombyx mori. Insect Science, 2020, 27(4):675-686.
26. Changfei Guo, Junhong Qiu, Yuwei Hu, Peiping Xu, Yingqi Deng, Ling Tian, Yiyun Wei, Wen Sang, Yutao Liu, Baoli Qiu. Silencing of V-ATPase-E gene causes midgut apoptosis of Diaphorina citri and affects its acquisition of Huanglongbing pathogen. Insect Sci, 2023, 30(4):1022-1034.
27. Daniele Bruno, Aurora Montali, Marzia Gariboldi, Anna Katarzyna Wrońska, Agata Kaczmarek, Amr Mohamed, Ling Tian, Morena Casartelli, Gianluca Tettamanti. Morphofunctional characterization of hemocytes in black soldier fly larvae. Insect Sci, 2023, 30(4):912-932.
28. Qinghui Tu, Jianhao Deng, Miaomiao Di, Xiaorong Lin, Zhongzheng Chen, Bin Li, Ling Tian, Yuanyuan Zhang. Reproductive toxicity of polystyrene nanoplastics in Drosophila melanogaster under multi-generational exposure. Chemosphere, 2023, 330:138724.
29. Daniele Bruno, Aurora Montali, Maristella Mastore, Maurizio Francesco Brivio, Amr Mohamed, Ling Tian, Annalisa Grimaldi, Morena Casartelli, Gianluca Tettamanti. Insights into the immune response of the black soldier fly larvae to bacteria. Front Immunol, 2021, 12:745160.
30. Huili Qiao, Jingya Wang, Yuanzhuo Wang, Juanjuan Yang, Bofan Wei, Miaomiao Li, Bo Wang, Xiaozhe Li, Yang Cao, Ling Tian, Dandan Li, Lunguang Yao, Yunchao Kan. Transcriptome analysis reveals potential function of long non-coding RNAs in 20-hydroxyecdysone regulated autophagy in Bombyx mori. BMC Gen, 2021, 22(1):374.
31. Marco Bonelli, Daniele Bruno, Matteo Brilli, Novella Gianfranceschi, Ling Tian, Gianluca Tettamanti, Silvia Caccia, Morena Casartelli. Black Soldier Fly Larvae Adapt to Different Food Substrates through Morphological and Functional Responses of the Midgut. Int J Mol Sci, 2020, 21(14):4955.
25, 中国, 202010473672.X (专利)
(2) 田铃; 李荣松; 吴坤钟; 邓健浩; 一种组合物及其抗菌应用, 2020-10-22, 中国, 202011137398.5
(专利)
(3) 田铃; 吴坤钟; 曹阳; 黄志君; 一种细胞-寄生菌总DNA的提取试剂、试剂盒及应用与提取方法, 2020-
11-6, 中国, ZL201910316972.4
本团队长期从事昆虫先天免疫的研究，在国内较早开展了家蚕细胞自噬和凋亡研究。近 10 年来，通过与国内外合作，获得了一定的原创性研究成果：①在昆虫抗菌肽功能分化和体液免疫机制方向，先后在国际期刊 Insect Biochem Mol Biol（2012，2020）、PLoS ONE（2011）、JBB（2009）、Gene（2006）等发表论文 7 篇，在国内核心期刊发表论文 19 篇；②在家蚕细胞自噬和凋亡方向上，先后在 Autophagy（2010，2013，2016，2021）、Scientific Reports（2015）、PLoS ONE（2012）、Apoptosis（2011）、Can. J. Zool（2010，2011）等发表论文多篇。先后承担国家“973计划”项目、国家“863”计划项目、国家自然科学基金项目、广东省科技计划项目等近20项。实验室建立和掌握了昆虫先天免疫、细胞自噬研究的平台和技术方法，具有从事家蚕细胞自噬研究的丰富经验。
