更新日期：2025年8月10日
个人简介
华南农业大学植物病理学/微生物学，研究员，博士生导师，广东省珠江人才计划第四届“群体微生物基础理论与前沿技术创新团队” 核心成员。2011年在浙江大学获博士学位，2011-2014年新加坡新科局分子细胞生物研究院博士后研究，2014年起在华南农业大学任教。主要围绕甘蔗、玉米、柑橘、蔬菜等重要作物的黑粉病、溃疡病、枯萎病、软腐病等开展研究。先后主持973项目子课题、国家重点研发项目子课题、国家自然科学基金面上项目、广东省自然科学基金面上项目、广东省科技计划项目等十几项；以第一作者或通讯作者在PNAS, International Journal of Biological Macromolecules, Journal of Genetics and Genomics, Journal of Agricultural Food and Chemistry, Molecular Plant Pathology, Environmental Microbiology等期刊发表论文多篇；以第一发明人获国家发明专利授权十余项。
工作经历
1. 2002-2008 新加坡新科局分子细胞生物研究院，Research officer; 2. 2011-2014 新加坡新科局分子细胞生物研究院，博士后；3. 2014-2019 华南农业大学 副教授； 4. 2020-至今 华南农业大学 研究员
教育经历
2008-2011, 浙江大学 博士
社会、学会及学术兼职
广东省微生物学会第十届理事会理事
研究领域
实验室致力于甘蔗、玉米、水稻、柑橘、蔬菜等重要作物的黑粉病、溃疡病、枯萎病、软腐病等研究，主要围绕：1）鉴定病原微生物种类； 2）解析病原菌的侵染致病机制；3）挖掘寄主植物的关键抗病基因；4）挖掘具有生物防治潜力的微生物资源；5）研发绿色防控新技术等。
科研项目
1. 国家自然科学基金面上项目，“G蛋白偶联受体SsPra内吞调控甘蔗鞭黑粉菌结合管形成的分子机制”（2025-2028，在研）。
2. “十四五”重点研发项目子课题， “高抗高产籼稻新种质创制”（2024-2027，在研）。
3. 国家自然科学基金区域联合重点项目，“微生物组-病原真菌-甘蔗互作调控甘蔗重要真菌病害的机制研究”（2024-2027，在研）。
4. 广东省自然科学基金面上项目，甘蔗鞭黑粉菌SsHog1调控性信息素应答因子SsPrf1的分子机制 (2024-2026，在研)。
5. “十四五”重点研发项目子课题， “华南柑橘产区溃疡病菌、果园生态对溃疡病流行成灾的影响”（2022-2026，在研） 。
发表论文
代表性论文 (#co-author; *corresponding author)
1. Yongqi Wen#, Xiaoming Pu#, Mingfa Lv, Ruqing Feng, Sheng Yang, Xiyue Gao, Changqing Chang,*and Zeling Xu*.Unveiling the Antagonistic Mechanism of Pseudomonas aeruginosa Y010 Directs Targeted Genetic Screening for Enhanced Biocontrol Efficacy. Journal of Agricultural and Food Chemistry. 2025, 73, 28, 17685–17695.
2. Huan Jia, Rongrong Wu, Lei Li, Li Zhang, Xian Sun, Xiaonan Feng, Yifan Wang, Enping Cai, Shuquan Sun, Changqing Chang*. Induced cuproptosis by targeting the ESCRT-III complex potentiates copper-based control of smut diseases. International Journal of Biological Macromolecules 2025, 305 141292.
3. Enping Cai #,*Jiaru Deng #, Ruqing Feng, Song Tang , Huan Jia , Li Zhang, Lei Li , and Changqing Chang*. Cytochrome P450 enzyme Cyp86 regulates fatty acid metabolism essential for mating/filamentation of Sporisorium scitamineum. Virulence 2024 Aug 23;15(1):2395833.
4. Shaofang Chen#, Wenjuan Chen#, Haoran Song, Mingqiu Liu, Sandhya Mishra, Mohamed A. Ghorab, Shaohua Chen and Changqing Chang *. Microorganism-Driven 2,4-D Biodegradation: Current Status and Emerging Opportunities. Molecules 2024, 29(16),10.3390/ molecules 29163869.
5. Enping Cai, Rong Zeng, Ruqing Feng, Li Zhang, Lei Li, Huan Jia, Wenqiang Zheng, Shaofang Chen, Meixin Yan, and Changqing Chang*. Discovery of N-Benzyl-4-(1-bromonaphthalen-2-yl)oxybutan-1-amine as a Potential Antifungal Agent against Sporidia Growth and Teliospore Germination of Sporisorium scitamineum. Journal Agricultural and Food Chemistry 2024, 72, 7, 3325–3333.
6. Enping Cai, Huan Jia, Ruqing Feng, Wenqiang Zheng, Lei Li, Li Zhang, Zide Jiang, Changqing Chang*. Cytochrome c-Peroxidase Modulates ROS Homeostasis to Regulate the Sexual Mating of Sporisorium scitamineum. Microbiology Spectrum 2023 Oct 11:e0205723.
7. Shaofang Chen, Wenjuan Chen, Yaohua Huang, Ming Wei, Changqing Chang*. Insights into the metabolic pathways and biodegradation mechanisms of chloroacetamide herbicides. Environmental Research 2023 Jul 15;229:115918.
8. Enping Cai#, Meixin Yan#, Xian Sun, Rong Zeng, Wenqiang Zheng, Yizhen Deng, Zide Jiang and Changqing Chang*. Kinase Hog1 and Adr1 Opposingly Regulate Haploid Cell Morphology by Controlling Vacuole Size in Sporisorium scitamineum. Journal of Fungi 2022, 8(8), 865.
9. Kaihuai Li#, Jinxing Liao #, Ming Wei, Shanxu Qiu, Weiyin Wu, Yancun Zhao, Haihong Wang, Qiongguang Liu, Fengquan Liu * and Changqing Chang *. The Xanthomonas citri reverse fitness deficiency by activating a novel β-glucosidase under low osmostress. Frontiers in Microbiology 2022, 13:887967.
10. Yufan Chen#, Yanchang Li#, Minya Zhu, Mingfa Lv, Zhiqing Liu, Zhongqiao Chen, Ying Huang, Weihan Gu, Zhibin Liang, Changqing Chang, Jianuan Zhou, Lianhui Zhang*, Qiongguang Liu*. The GacA-GacS Type Two-component System modulates the Pathogenicity of Dickeya oryzae EC1 mainly by Regulating the Production of Zeamines. Mol Plant Microbe Interact 2022 May;35(5):369-379.
11. Enping Cai, Shuquan Sun, Yizhen Deng, Peishen Huang, Xian Sun, Yuting Wang, Changqing Chang,* and Zide Jiang *. Histidine Kinase Sln1 and cAMP/PKA Signaling Pathways Antagonistically Regulate Sporisorium scitamineum Mating and Virulence via Transcription Factor Prf1. Journal of Fungi 2021 Jul 28;7(8):610.
12. Enping Cai, Lingyu Li, Yizhen Deng, Shuquan Sun, Huan Jia, Rongrong Wu, Lianhui Zhang, Zide Jiang*, Changqing Chang*. MAP kinase Hog1 mediates a cytochrome P450 oxidoreductase to promote the Sporisorium scitamineum cell survival under oxidative stress. Environmental Microbiology 2021 Jun;23(6):3306-3317.
13. 蔡恩平, 梅丹, 张小萌, 孙贤, 李玲玉, 吴熔熔, 邓懿祯, 姜子德*, 常长青*. 甘蔗鞭黑粉菌原生质体转化DNA双片段的基因敲除方法的建立。菌物学报, 2020,22 December,39(12): 2314-2327。
14. Jinxing Liao#, Kaihuai Li#, Jinpei Wang, Jiaru Deng, Qiongguang Liu, Changqing Chang*. RNA-seq analysis provides insights into the cold stress responses of Xanthomonas citri pv. citri. BMC genomics 2019 Nov 6; 20(1):807.
15. Chao Wang#, Fuzhou Ye#, Changqing Chang#, Xiaoling Liu, Jianhe Wang, Jinpei Wang, Xinfu Yan, Qinqin Fu, Jiannuan Zhou, Shaohua Chen, Yonggui Gao*, and Lianhui Zhang*. Agrobacteria reprogram virulence gene expression by controlled release of host conjugated signals. PNAS 2019 Oct 29;116(44):22331-22340. (Faculty of 1000).
16. Changqing Chang #*, Enping Cai #, Yizhen Deng, Mei Dan, Qiu Shanxu, Chen Baoshan, LianHui Zhang, Zide Jiang*. cAMP/PKA Signaling Pathway Regulates Redox homeostasis essential for Sporisorium scitamineum Mating/Filamentation and Virulence. Environmental Microbiology 2019 Mar; 21(3):959-971.
17. Shuquan Sun, Yizhen Deng, Enping Cai, Meixin Yan, Lingyu Li, Baoshan Chen, Changqing Chang*, Zide Jiang*. The Farnesyltransferase β-Subunit Ram1 Regulates Sporisorium scitamineum Mating, Pathogenicity and Cell Wall Integrity. Frontiers in Microbiology 2019 May 8;10:976.
18. Yixu Wang#, Yizhen Deng#, Guobing Cui, Chengwei Huang, Bin Zhang, Changqing Chang, Zide Jiang and Lianhui Zhang*. The AGC Kinase SsAgc1 Regulates Sporisorium scitamineum Mating/Filamentation and Pathogenicity. mSphere 2019 May 29;4(3).
19. Chunyan Zhang, Mingfa Lv, Wenfang Yin, Tingyan Dong, Changqing Chang, Yansong Miao, Yantao Jia, Yinyue Deng*. Xanthomonas campestris Promotes Diffusible Signal Factor Biosynthesis and Pathogenicity by Utilizing Glucose and Sucrose from Host Plants. Molecular Plant Microbe Interaction. 2019 Feb;32(2):157-166.
20. Bin Zhang, Guobing Cui, Changqing Chang, Yixu Wang, Haoyang Zhang, Baoshan Chen, Yizhen Deng *, Zide Jiang*. The autophagy gene ATG8 affects morphogenesis and oxidative stress tolerance in Sporisorium scitamineum. Journal of Integrative Agriculture 2018, 17(0): 60345-7.
21. Jianuan Zhou#, Haibao Zhang#, Mingfa Lv, Yufan Chen, Lisheng Liao, Yinyin Cheng, Shiyin Liu, Shaohua Chen, Fei He, Zining Cui, Zide Jiang, Changqing Chang*, and Lianhui Zhang*. SlyA regulates phytotoxin production and virulence in Dickeya zeae EC1. Molecular Plant Pathology 2016. 17 (9) :1398-1408.
22. Meixin Yan, Weijun Dai, Enping Cai, Yizhen Deng, Changqing Chang, Zide Jiang*, and Lianhui Zhang*. Transcriptome analysis of Sporisorium scitamineum reveals critical environmental signals for fungal sexual mating and filamentous growth. BMC Genomics 2016,17 (354).
23. Meixin Yan#, Enping Cai#, Jianuan Zhou, Changqing Chang, Pinggen Xi, Wankuan Shen, Zide Jiang, Yizhen Deng, and Lianhui Zhang*. A Dual-Color Imaging System for Sugarcane Smut Fungus Sporisorium scitamineum. Plant disease 2016,100 (12):2357-2362.
24. Lu Gong, Hongjian Gong, Xiao Pan, Changqing Chang, Zhao Ou, Shengfan Ye, Le Yin, Lina Yang, Ting Tao, Zhenhai Zhang, Cong Liu, David Lane, Jinrong Peng* and ChenJun*. p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage. Cell Research 2015, 25(3):351-69.
25. Chen Shaohua, Changqing, Chang, Deng, Y, An, S, Dong, Y. H., Zhou, J, Hu, M, Zhong, G, and Zhang, L. Fenpropathrin Biodegradation Pathway in Bacillus sp DG-02 and Its Potential for Bioremediation of Pyrethroid-Contaminated Soils. Journal Agricultural and Food Chemistry 2014, 62 (10):2147-2157.
26. Zhao Ou#, Le Yin#, Changqing Chang#, Jinrong Peng*, Jun Chen*. Protein Interaction Between p53 and Δ113p53 Is Required for the Anti-Apoptotic Function of Δ113p53. Journal of Genetics and Genomics 2014, 41 (2):53-62. (Cover story).
27. Jasmine Lee, Jien Wu, Yinyue Deng, Jing Wang, Chao Wang, Jianhe Wang, Changqing Chang, Yihu Dong, Paul Williams, Lianhui Zhang*. A cell-cell communication signal integrates quorum sensing and stress response. Nature Chemical Biology 2013, 9 (5):339-43. (Faculty of 1000).
28. Shaohua Chen, Yihu Dong, Changqing Chang, Yinyue Deng, Xifeng Zhang, G Zhong, Haiwei Song, Meiying Hu*, Lianhui Zhang*. Characterization of a novel cyfluthrin-degrading bacterial strain Brevibacterium aureum and its biochemical degradation pathway. Bioresoure Technology 2013.132:16-23.
29. Yingying Cheng, Xiaoling Liu, Shuwen An, Changqing Chang, Yuanqiang Zou, Luhao Huang, Jin Zhong, Qiongguang Liu, Zide Jiang, Jianuan Zhou*, Lian-Hui Zhang*. A Non-ribosomal Peptide Synthase Containing A Stand-alone Condensation Domain Is Essential for Phytotoxin Zeamine Biosynthesis. Mol Plant Microbe Interact 2013, Nov;26(11):1294-301.
30. Lian Zhou# , JiaYuan Wang#, Ji'en Wu, Jianhe Wang, Alan Poplawsky, Shuangjun Lin, Bangshang Zhu, Changqing Chang, Tielin Zhou, LianHui Zhang*, YaWen He*. The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways. Molecular Mirobiol 2013, Jan;87(1):80-93.
31. Jingang Liu#, Lu Gong#, Changqing Chang#, Cong Liu, Jinrong Peng*, Jun Chen*. Development of Novel Visual-Plus Quantitative Analysis Systems for Studying DNA Double-Strand Break Repairs in Zebrafish. Journal of Genetics and Genomics. 2012, 39(9):489-02.
32. Yinyue Deng*, Nadine Schmid, Chao Wang, Jianhe Wang, Gabriella Pessi, Donghui Wu, Jasmine Lee, Claudio Aguilar, Christian H Ahrens, Changqing Chang, Haiwei Song, Leo Eberl, Lian-Hui Zhang*. Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover. PNAS 2012, 109(38):15479-84.
33. Changqing Chang, Minjie Hu, Zhihui Zhu, Li Jan Lo, Jun Chen*, Jinrong Peng*. liver-enriched gene 1a and 1b Encode Novel Secretory Proteins Essential for Normal Liver Development in Zebrafish. PloS One 2011, 6(8):e22910.
34. Shulan Yang, Sharon Siqi Aw, Changqing Chang, Svetlana Korzh,Vladimir Korzh, Jinrong Peng*. Depletion of Bhmt elevates sonic hedgehog Transcript Levels and Increases β-Cell Number in Zebrafish. Endocrinology 2011, 152(12):4706-4717.
35. Susheng Song#, Tiancong Qi#, Huang Huang, Qingcuo Ren, Dewei Wu, Changqing Chang, Wen Peng, Yule Liu, Jinrong Peng*, Daoxin Xie*. The Jasmonate-ZIM Domain ProteinsInteract with the R2R3-MYB Transcription Factors MYB21 and MYB24 to Affect Jasmonate-Regulated Stamen Development in Arabidopsis. The Plant Cell 2011, 23:1000-1013.
36. Jun Chen, Sok Meng Ng#, Changqing Chang#, Zhenhai Zhang, Jean-Christophe Bourdon, David P Lane*, Jinrong Peng *. p53 isoform ∆113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish. Genes & Dev 2009, 23:278-290 (Faculty of 1000).
37. Changqing Chang, Yinghui Cheng, Meimei Xiang, Zide Jiang*, Peikun Chi. New species of phomopsis on woody plants in Fujian province. Mycosystema 2005, 24: 6-11.
38. Changqing Chang, Pinggen Xi, Meimei Xiang, Zide Jiang*, Peikun Chi. New species of phomopsis on woody plants in Hunan province. Mycosystema 2005, 24: 145-154.
39. Fuquan Liu#, Weimin Ni#, Megan E.Griffith#, Zhiyuan Huang, Changqing Chang, Wen Peng, Hong Ma*, Daoxin Xie*. The ASK1 and ASK2 Genes Are Essential for Arabidopsis Early Development. The Plant Cell 2004,16: 5-20.
科研创新
以第一发明人授权国家发明专利12项。
教学活动
本科生课程：《乡村振兴与微生物学应用》；研究生课程：《分子生物学原理与技术》、《高级植物病原细菌学》、《微生物资源与利用》、《分子生物学植物保护进展》