更新日期：2026年1月7日
个人简介
华南农业大学植物病理学/微生物学，研究员，博士生导师，广东省珠江人才计划第四届“群体微生物基础理论与前沿技术创新团队” 核心成员。2011年在浙江大学获博士学位，2011-2014年新加坡新科局分子细胞生物研究院博士后研究，2014年起在华南农业大学任教。主要围绕甘蔗、玉米、柑橘、蔬菜等重要作物的黑粉病、溃疡病、枯萎病、软腐病等开展研究。先后主持973项目子课题、国家重点研发项目子课题、国家自然科学基金面上项目、广东省自然科学基金面上项目、广东省科技计划项目等十几项；以第一作者或通讯作者在PNAS, International Journal of Biological Macromolecules, Journal of Genetics and Genomics, Journal of Agricultural Food and Chemistry, Molecular Plant Pathology, Environmental Microbiology等期刊发表论文多篇；以第一发明人获国家发明专利授权十余项。
工作经历
1. 2002-2008 新加坡新科局分子细胞生物研究院，Research officer; 2. 2011-2014 新加坡新科局分子细胞生物研究院，博士后；3. 2014-2019 华南农业大学 副教授； 4. 2020-至今 华南农业大学 研究员
教育经历
2008-2011, 浙江大学 博士
社会、学会及学术兼职
广东省微生物学会第十届理事会理事
研究领域
实验室致力于甘蔗、玉米、水稻、柑橘、蔬菜等重要作物的黑粉病、溃疡病、枯萎病、软腐病等研究，主要围绕：1）鉴定病原微生物种类； 2）解析病原菌的侵染致病机制；3）挖掘寄主植物的关键抗病基因；4）挖掘具有生物防治潜力的微生物资源；5）研发绿色防控新技术等。
科研项目
1. 国家自然科学基金面上项目，“G蛋白偶联受体SsPra内吞调控甘蔗鞭黑粉菌结合管形成的分子机制”（2025.01-2028.12，在研）。
2. “十四五”重点研发项目子课题， “华南籼稻抗病基因的挖掘及利用”（2024.12-2027.11，在研）。
3. 国家自然科学基金区域联合重点项目，“微生物组-病原真菌-甘蔗互作调控甘蔗重要真菌病害的机制研究”（2024.01-2027.12，在研）。
4. 广东省自然科学基金面上项目，甘蔗鞭黑粉菌SsHog1调控性信息素应答因子SsPrf1的分子机制 (2024.01-2026.12，在研)。
5. “十四五”重点研发项目子课题， “华南柑橘产区溃疡病菌、果园生态对溃疡病流行成灾的影响”（2022.09-2026.12，在研） 。
发表论文
代表性论文 (#co-author; *corresponding author)
1. Huan Jia#, Enping Cai#, Weilun Xu and Changqing Chang*. When 1–2 °C Matters: Climate Warming Reshapes Maize Disease and Resistance Networks. Journal of Experimental Botany.2026, DOI:10.1093/jxb/eraf495.
2. Bo Xiong# , Nannan Zhang #, Yirong Guo, Yawen Lei , Jiayun Wu, Changqing Chang *, Enping Cai *. Phenylacetate hydroxylase SsPhacA modulates p-coumaric acid accumulation to regulate the mating/filamentation of Sporisorium scitamineum. 2025，Mol Plant Pathol. 2025; 26: e70188 DOI: 10.1111 /mpp.7018.
3. Yongqi Wen#, Xiaoming Pu#, Mingfa Lv, Ruqing Feng, Sheng Yang, Xiyue Gao, Changqing Chang, *and Zeling Xu*. Unveiling the Antagonistic Mechanism of Pseudomonas aeruginosa Y010 Directs Targeted Genetic Screening for Enhanced Biocontrol Efficacy. Journal of Agricultural and Food Chemistry. 2025, 73, 28, 17685–17695.
4. Huan Jia, Rongrong Wu, Lei Li, Li Zhang, Xian Sun, Xiaonan Feng, Yifan Wang, Enping Cai, Shuquan Sun, Changqing Chang*. Induced cuproptosis by targeting the ESCRT-III complex potentiates copper-based control of smut diseases. International Journal of Biological Macromolecules 2025, 305 141292.
5. Enping Cai #*, Jiaru Deng #, Ruqing Feng, Song Tang , Huan Jia , Li Zhang, Lei Li , and Changqing Chang*. Cytochrome P450 enzyme Cyp86 regulates fatty acid metabolism essential for mating/filamentation of Sporisorium scitamineum. Virulence 2024 Aug 23;15(1):2395833.
6. Enping Cai, Rong Zeng, Ruqing Feng, Li Zhang, Lei Li, Huan Jia, Wenqiang Zheng, Shaofang Chen, Meixin Yan, and Changqing Chang*. Discovery of N-Benzyl-4-(1-bromonaphthalen-2-yl)oxybutan-1-amine as a Potential Antifungal Agent against Sporidia Growth and Teliospore Germination of Sporisorium scitamineum. Journal Agricultural and Food Chemistry 2024, 72, 7, 3325–3333.
7. Enping Cai, Huan Jia, Ruqing Feng, Wenqiang Zheng, Lei Li, Li Zhang, Zide Jiang, Changqing Chang*. Cytochrome c-Peroxidase Modulates ROS Homeostasis to Regulate the Sexual Mating of Sporisorium scitamineum. Microbiology Spectrum 2023 Oct 11:e0205723.
8. Shaofang Chen, Wenjuan Chen, Yaohua Huang, Ming Wei, Changqing Chang*. Insights into the metabolic pathways and biodegradation mechanisms of chloroacetamide herbicides. Environmental Research 2023 Jul 15;229:115918.
9. Enping Cai#, Meixin Yan#, Xian Sun, Rong Zeng, Wenqiang Zheng, Yizhen Deng, Zide Jiang and Changqing Chang*. Kinase Hog1 and Adr1 Opposingly Regulate Haploid Cell Morphology by Controlling Vacuole Size in Sporisorium scitamineum. Journal of Fungi 2022, 8(8), 865.
10. Enping Cai, Lingyu Li, Yizhen Deng, Shuquan Sun, Huan Jia, Rongrong Wu, Lianhui Zhang, Zide Jiang*, Changqing Chang*. MAP kinase Hog1 mediates a cytochrome P450 oxidoreductase to promote the Sporisorium scitamineum cell survival under oxidative stress. Environmental Microbiology 2021 Jun;23(6):3306-3317.
11. 蔡恩平, 梅丹, 张小萌, 孙贤, 李玲玉, 吴熔熔, 邓懿祯, 姜子德*, 常长青*. 甘蔗鞭黑粉菌原生质体转化DNA双片段的基因敲除方法的建立。菌物学报, 2020,22 December,39(12): 2314-2327。
12. Jinxing Liao#, Kaihuai Li#, Jinpei Wang, Jiaru Deng, Qiongguang Liu, Changqing Chang*. RNA-seq analysis provides insights into the cold stress responses of Xanthomonas citri pv. citri. BMC genomics 2019 Nov 6; 20(1):807.
13. Chao Wang#, Fuzhou Ye#, Changqing Chang#, Xiaoling Liu, Jianhe Wang, Jinpei Wang, Xinfu Yan, Qinqin Fu, Jiannuan Zhou, Shaohua Chen, Yonggui Gao*, and Lianhui Zhang*. Agrobacteria reprogram virulence gene expression by controlled release of host conjugated signals. PNAS 2019 Oct 29;116(44):22331-22340. (Faculty of 1000).
14. Changqing Chang #*, Enping Cai #, Yizhen Deng, Mei Dan, Qiu Shanxu, Chen Baoshan, LianHui Zhang, Zide Jiang*. cAMP/PKA Signaling Pathway Regulates Redox homeostasis essential for Sporisorium scitamineum Mating/Filamentation and Virulence. Environmental Microbiology 2019 Mar; 21(3):959-971.
15. Jianuan Zhou#, Haibao Zhang#, Mingfa Lv, Yufan Chen, Lisheng Liao, Yinyin Cheng, Shiyin Liu, Shaohua Chen, Fei He, Zining Cui, Zide Jiang, Changqing Chang*, and Lianhui Zhang*. SlyA regulates phytotoxin production and virulence in Dickeya zeae EC1. Molecular Plant Pathology 2016. 17 (9) :1398-1408.
16. Zhao Ou#, Le Yin#, Changqing Chang#, Jinrong Peng*, Jun Chen*. Protein Interaction Between p53 and Δ113p53 Is Required for the Anti-Apoptotic Function of Δ113p53. Journal of Genetics and Genomics 2014, 41 (2):53-62. (Cover story).
17. Jasmine Lee, Jien Wu, Yinyue Deng, Jing Wang, Chao Wang, Jianhe Wang, Changqing Chang, Yihu Dong, Paul Williams, Lianhui Zhang*. A cell-cell communication signal integrates quorum sensing and stress response. Nature Chemical Biology 2013, 9 (5):339-43. (Faculty of 1000).
18. Jingang Liu#, Lu Gong#, Changqing Chang#, Cong Liu, Jinrong Peng*, Jun Chen*. Development of Novel Visual-Plus Quantitative Analysis Systems for Studying DNA Double-Strand Break Repairs in Zebrafish. Journal of Genetics and Genomics. 2012, 39(9):489-02.
19. Changqing Chang, Minjie Hu, Zhihui Zhu, Li Jan Lo, Jun Chen*, Jinrong Peng*. liver-enriched gene 1a and 1b Encode Novel Secretory Proteins Essential for Normal Liver Development in Zebrafish. PloS One 2011, 6(8):e22910.
20. Susheng Song#, Tiancong Qi#, Huang Huang, Qingcuo Ren, Dewei Wu, Changqing Chang, Wen Peng, Yule Liu, Jinrong Peng*, Daoxin Xie*. The Jasmonate-ZIM Domain ProteinsInteract with the R2R3-MYB Transcription Factors MYB21 and MYB24 to Affect Jasmonate-Regulated Stamen Development in Arabidopsis. The Plant Cell 2011, 23:1000-1013.
21. Jun Chen, Sok Meng Ng#, Changqing Chang#, Zhenhai Zhang, Jean-Christophe Bourdon, David P Lane*, Jinrong Peng *. p53 isoform ∆113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish. Genes & Dev 2009, 23:278-290 (Faculty of 1000).
22. Fuquan Liu#, Weimin Ni#, Megan E.Griffith#, Zhiyuan Huang, Changqing Chang, Wen Peng, Hong Ma*, Daoxin Xie*. The ASK1 and ASK2 Genes Are Essential for Arabidopsis Early Development. The Plant Cell 2004,16: 5-20.
科研创新
以第一发明人授权国家发明专利12项。
教学活动
本科生课程：《乡村振兴与微生物学应用》，《菌物学概论与应用》；硕士、博士研究生课程：《分子生物学原理与技术》、《高级植物病原细菌学》、《微生物资源与利用》、《分子生物学植物保护进展》