目录
更新日期:2021年4月8日
姓 名 崔紫宁 性 别
出生年月 1981年10月 籍贯 内蒙古
民 族 汉族 政治面貌 中共党员
最后学历 博士研究生 最后学位 理学博士学位
技术职称 教授 导师类别 博导
行政职务 Email ziningcui@scau.edu.cn
工作单位 群体微生物研究中心/植物保护学院 邮政编码 510642
通讯地址 科技楼405
单位电话 020-85288229
个人主页
个人简介
研究兴趣:活性小分子的设计合成与作用机制研究,农药学,药物化学。主要从事①病原-寄主跨界通讯系统抑制剂的设计合成与互作机制研究;②糖化学及含杂环有机分子的设计合成以及生物活性研究;③群体感应抑制剂的设计合成。
至今发表研究论文50余篇,申请中国发明专利20项,获得授权6项。
主持国家自然科学基金3项,广东省杰出青年基金项目1项,广东省国际联合基金1项,参与973项目1项,国家重点研发计划1项,主持日本学术振兴会(JSPS)项目2项,主持和参与省部级项目9项。入选2015年“珠江科技新星”,同年入选我校省级“千百十人才培养工程”重点培养对象。所在研究团队入选华南农业大学“十佳科研团队”,并于2016年荣获第六届“中国侨界贡献(创新团队)奖。
以日本学术振兴会(JSPS)外籍特别研究员和外籍聘用研究员的身份在日本千叶大学从事科研工作4年,2017年入选国家留学基金委青年骨干教师出国研修项目,以访问学者身份在美国的Scripps研究所Jin-Quan Yu院士实验室进行访问研究。
工作经历
•2016.8 至今           华南农业大学群体微生物研究中心,亚热带农业生物资源保护与利用国家重点实验室
                               广东省微生物信号与作物病虫害防控重点实验室                                          教授
•2017.12-2018.12  美国斯克利普斯研究所(The Scripps Research Institute)化学系            访问学者
•2017.6-2017.8      日本千叶大学                      JSPS外籍聘用研究员
·2013.9-2016.7       华南农业大学                              副研究员
·2012.4-2013.8       日本千叶大学                         JST博士后研究员
·2012.8-2012.11     北京大学                                   访问学者
·2010.8-2012.7       日本千叶大学                      JSPS外籍特别研究员
教育经历
·2000.9-2004.7    中国农业大学国家化学理科基地班                本科
·2004.9-2010.6    中国农业大学理学院应用化学系                硕博连读
·2008.6-2008.7    中国科学院研究生院      全国“生物化学与分子生物学”研究生暑期学校
·2008.10-2009.9   日本千叶大学                         联合培养博士生
获奖、荣誉称号
•2020年    广东省杰出青年基金获得者
•2017年    入选国家留学基金委青年骨干教师出国研修项目
•2017年    日本学术振兴会(JSPS)外籍聘用研究员JSPS Invitational Fellowship (Short-term)
•2016年    荣获第六届中国侨界贡献(创新团队)奖——微生物群体感应创新团队
•2015年    入选华南农业大学“十佳科研团队——微生物信号与群体感应团队”
•2015年    入选广州市“珠江科技新星”
•2015年    入选广东省省级“千百十人才培养工程”重点培养对象
•2012年    日本科学技术振兴机构(JST)博士后研究员
•2010年    日本学术振兴会(JSPS)外籍特别研究员
•2009年    中国农业大学校长奖学金
•2008年    入选国家建设高水平大学公派研究生项目,国家留学基金委员会
•2006年    北京农药学会农药奖学金
•2004年    北京农药学会农药奖学金
社会、学会及学术兼职
担任《中国化学快报》第三届青年编委会委员;广东省植物保护学会第九届理事会理事;广东省微生物学会第十届理事会理事
研究领域
主要从事①病原-寄主跨界通讯系统抑制剂的设计合成与互作机制研究;②糖化学及含杂环有机分子的设计合成以及生物活性研究;③群体感应抑制剂的设计合成。
科研项目
在研项目:
1. 国家自然科学基金(32072450):水稻白叶枯病菌III型分泌系统抑制剂作用靶标的发现与互作机制的研究。2021年1月-2024年12月,项目主持人。
2. 广东省杰出青年基金(2021B1515020107):植物病原-寄主跨界通讯系统抑制剂的创制及作用机制研究。2021年1月-2024年12月,项目主持人。
3. 旱区作物逆境生物学国家重点实验室开放课题(CSBAAKF2021009):稻黄单胞菌T3SS抑制剂作用靶标的发现与互作机制初探。2021年1月-2022年12月,项目主持人。
4. 广东省国际科技合作专题(2020A0505100048):病原细菌III型分泌系统抑制剂的筛选及病害防控研究。2020年9月-2022年12月,项目主持人。
5. 佛山海关综合技术中心:跨境邮寄物携带水果检疫性细菌病害的危害及药剂防控措施的筛选。2020年11月-2022年10月,项目主持人。
6. 国家重点研发计划(2017YFD0200500):农业生物药物分子靶标发现与绿色药物分子设计。2017年7月-2021年6月,骨干成员(子课题主持)。
7. 广东省自然科学基金(2018A030313414):基于五环三萜为先导结构的新型流感病毒进入抑制剂的构效关系及作用机制研究。2018年5月-2021年4月,主要成员
8. 广州市科技计划项目(201804010457):熊果酸衍生物作为新型H5N1进入抑制剂的构效关系及作用机制研究。2018年4月-2021年3月,主要成员


已结题项目:
1. 国家自然科学基金(31570122):病原细菌多胺信号转导系统抑制剂的设计与合成。2016年1月-2019年12月,项目主持人。
2. 国家自然科学基金(21102173):糖基修饰水杨酸衍生物的合成及其抗病诱导活性研究。2012年1月-2014年12月,项目主持人。
3. 973计划(2015CB150600):微生物群体感应通讯系统与病害防控基础研究。2015年1月-2019年12月,骨干成员(子课题主持)。
4. 广东省公益研究与能力建设专项(2014A020210019):以拓扑异构酶II为靶点的新型氧杂蒽酮糖基缀合物的合成及构效关系研究。2015年1月-2017年12月,项目主持人。
5. 广东省普通高校特色创新项目(自然科学)(2014KTSCX031):糖缀合物作为植物抗病诱导剂的设计合成及其作用机制研究。2015年1月-2017年12月,项目主持人。
6. 广州市“珠江科技新星”专项(201506010029):基于细菌群体感应信号分子的抑制剂设计与合成及作物病害防控。2015年4月-2018年3月,项目主持人。
7. JSPS Postdoc Fellowship (P10100):Molecular design, synthesis and bioactivity evaluation of novel glycosyl hydrazines. From the Japan Society for the Promotion of Science, Aug./2010 to Jul./2012,项目主持人。
发表论文
1 Ahmed,Wasim; Huang, Zi-Hao; Cui, Zi-Ning* Tang, Ri-Yuan*. Design and synthesis of unique thiazoloisoquinolinium thiolates and derivatives. Chin. Chem. Lett., 2021, in press.
2 He, Min#; Gu, Jingwen#; Li, Sicheng#; Xiang, Xuwen; Jiang, Shan; Cui, Zi-Ning*. Design, synthesis and fungicidal activities of phenazine-1-carboxamida conjugates of 1,3,4-thia(oxa)diazole. Chin. J. Pestic. Sci., 2021, 23(2), 287-295.
3 Li, Ya-Sheng#; He, Min#; Zhou,Tao-Shun; Wang, Qin; He, Lulu; Wang, Si-Jia; Hu, Bei; Wei, Bin*; Wang, Hong*; Cui, Zi-Ning*. 2,5-Disubstituted furan derivatives containing 1,3,4-thiadiazole moiety as potent α-glucosidase and E. coli β-glucuronidase inhibitors. Eur. J. Med. Chem., 2021, 216, 113336.
4 Li, Ya-Sheng#; Yang, Xi#; Zhao, Dong-Sheng#; Cai, Yue#; Huang, Zhi; Wu, Rui; Wang, Si-Jia; Liu, Gui-Jun; Wang, Jian; Bao, Xiao-Ze; Ye, Xin-Yi; Wei, Bin; Cui, Zi-Ning*; Wang, Hong*. Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell. Eur. J. Med. Chem., 2021, 216, 113322.
5 Fan, Zhoulong; Zhao, Shuai; Liu, Tao; Shen, Peng-Xiang; Cui, Zi-Ning; Zhuang, Zhe; Shao, Qian; Chen, Jason S.; Ratnayake, Anokha S.; Flanagan, Mark E.; Kolmel, Dominik K.; Piotrowski, David W.; Richardson, Paul; Yu, Jin-Quan. Merging C(sp3)-H activation with DNA-encoding, Chemical Science, 2020, 11(45), 12282-12288
6 Yinuo Lin#, Wasim Ahmed#, Min He#, Xuwen Xiang, Riyuan Tang*, Zi-Ning Cui*. Synthesis and Bioactivity of Phenyl Substituted Furan and Oxazole Carboxylic Acid Derivatives as Potential PDE4 Inhibitors. Eur. J. Med. Chem., 2020, 207, 112795.
7 Tao-Shun Zhou#, Bin Wei#, Min He#, Ya-Sheng Li, Ya-Kun Wang, Si-Jia Wang, Jian-Wei Chen, Hua-Wei Zhang, Zi-Ning Cui*, Hong Wang*. Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure-inhibitory activity relationships. J. Enzyme Inhib. Med. Chem., 2020, 35(1),1736-1742
8 Liao, Yixian; Ye, Yilu; Li, Sumei; Zhuang, Yilian; Chen, Liye; Chen, Jianxin; Cui, Zi-Ning; Huo, Lijian; Liu, Shuwen; Song, Gaopeng. Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PAN endonuclease. Eur. J. Med. Chem., 2020, 189, 112048.
9 Gao, Yong-Chao; Huang, Zi-Hao; Zhang, Zhao-Sheng; Xie, Jin-Xin; Cui, Zi-Ning*; Tang, Ri-Yuan*. Sulfite-Promoted C-H Fluoroalkyl Sulfuration of Imidazoheterocycles with Bromofluoroacetate and Elemental Sulfur. Synthesis, 2020, 52(17), 2541-2550.
10 Jia-Hao Chen, Wasim Ahmed, Minghua Li, Zhao-Dong Li, Zi-Ning Cui*, Ri-Yuan Tang*. TEMPO Mediated Synthesis of N-Fluoroalkyl Imidazolones by the Reaction of Imidazoles with Iodofluoroacetate. Adv. Synth. Catal., 2020, 362(1), 269-276.
11 Shan Jiang#, Min He#, Xu-Wen Xiang, Muhammad Adnan, Zi-Ning Cui*. Novel S-thiazol-2-yl-furan-2-carbothioate derivatives as potential T3SS inhibitors against Xanthomonas oryzae on rice. J. Agric. Food Chem., 2019, 67(43), 11867-11876. 10.1021/acs.jafc.9b04085.
12 Yixian Liao#, Xiuhua Jia#, Yongmei Tang, Sumei Li, Yipeng Zang, Lei Wang, Yongfeng Gao, Lijian Huo, Zi-Ning Cui*, Gaopeng Song*. Discovery of novel inhibitors of phosphodiesterase 4 with 1-phenyl-3,4-dihydroisoquinoline scaffold: structure-based drug design and fragment identification. Bioorg. Med. Chem. Lett., 2019, 29(22), 126720
13 Hui Tao#, Hao Tian#, Shan Jiang#, Xuwen Xiang, Yinuo Lin, Wasim Ahmed, Riyuan Tang*, Zi-Ning Cui*. Synthesis and biological evaluation of 1,3,4-thiadiazole derivatives as type III secretion system inhibitors against Xanthomonas oryzae. Pestic. Biochem. Physiol., 2019, 160, 87-94.
14 Wasim Ahmed#, Xiaojing Yan#, Dekun Hu#, Muhammad Adnan, Riyuan Tang*, Zi-Ning Cui*. Synthesis and Bioactivities of Novel Pyrazole Derivatives Containing 5-Phenyl-2-Furan. Bioorg. Med. Chem., 2019, 27(19), 115048.
15 Jian-Chao Deng, Jun-Rong Zhang, Jie-Cheng Huang, Zhi-Sheng Lai, Xin-Yu Tong, Zi-Ning Cui*, Riyuan Tang*. Direct Thiocarbamation of Imidazoheterocycles with Sulfur and Formamides via Dual C-H Sulfurization. Organic & Biomolecular Chemistry, 2019, 17, 7854-7857.
16 Shan Jiang#, Hui Li#, Wasim Ahmed#, Xuwen Xiang, Gaopeng Song*, Zi-Ning Cui*. Discovery of ethyl 2-nitro-3-arylacrylates molecules as T3SS inhibitor reducing the virulence of plant pathogenic bacteria Xanthomonas. Frontiers in Microbiology, 2019, 10, 1874.
17 Hui Tao#, Hao Tian#, Shan Jiang#, Xuwen Xiang, Wasim Ahmed, Riyuan Tang*, Zi-Ning Cui*. Synthesis and Bioactivity of 1,3-Thiazolidine-2-thione Derivatives against Type III Secretion System of Xanthomonas oryzae. Bioorg. Med. Chem., 2019, 27(15), 3364-3371.
18 Hui Tao#, Su-Su Fan#, Shan Jiang, Xuwen Xiang, Xiaojing Yan, Lian-Hui Zhang, Zi-Ning Cui*. Small molecule inhibitors specifically targeting type III secretion system of Xanthomonas oryzae on rice. Int. J. Mol. Sci., 2019, 20, 971
19 Ya-Sheng Li#, Xing-Yu Liu#, Dong-Sheng Zhao#, Yi-Xian Liao, Lian-Hui Zhang, Feng-Zhi Zhang, Gao-Peng Song*, Zi-Ning Cui*. Tetrahydroquinoline and tetrahydroisoquinoline derivatives as potential selective PDE4B inhibitors. Bioorg. Med. Chem. Lett., 2018, 28(19), 3271-3275
20 De-Kun Hu#, Dong-Sheng Zhao#, Min He, Hong-Wei Jin, Yong-Mei Tang, Lian-Hui Zhang, Gao-Peng Song*,Zi-Ning Cui*. Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors. Bioorg. Med. Chem. Lett., 2018, 28(19), 3276-3280
21 Xuwen Xiang#, Hui Tao#, Shan Jian, Lian-Hui Zhang, Zi-Ning Cui*. Synthesis and Bioactivity of Thiazolidin-2-cyanamide Derivatives against Type III Secretion System of Xanthomonas oryzae on Rice. Pestic. Biochem. Physiol., 2018, 149, 89-97
22 Ya-Sheng Li #, Dong-Sheng Zhao #, Xing-Yu Liu, Yi-Xian Liao, Hong-Wei Jin, Gao-Peng Song*, Zi-Ning Cui*. Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell. Eur. J. Med. Chem., 2018, 151, 546-556
23 Nan Cai, Caixiu Liu, Zhihui Feng, Xinghai Li*, Zhiqiu Qi, Mingshan Ji, Peiwen Qin, Wasim Ahmed, Zi-Ning Cui*. Design, synthesis and SAR of novel 2-glycinamide cyclohexyl sulfonamide derivatives against Botrytis cinerea. Molecules, 2018, 23,740
24 Gaopeng Song#, Sumei Li#, Dekun Hu#, Dongsheng Zhao, Junhua Li, Xiaojun Zheng, Yiming Guo, Xingyu Liu, Lian-Hui Zhang, Zi-Ning Cui*. Rational design of conformationally constrained oxazolidinone-fused 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors. Bioorg. Med. Chem., 2017, 25 (20), 5709-5717.
25 Xiang, Xuwen; Liu, Xingyu; Tao, Hui; Cui, Zi-Ning*; Zhang, Lian-Hui. Research progress of c-di-GMP inhibitors, Chin. J. Biotech., 2017, 33(9): 1466−1477
26 Liu, Xingyu; Xiang, Xuwen; Tao, Hui; Cui, Zi-Ning*; Zhang, Lian-Hui. Chemical agents that modulate bacterial biofilm formation and development, Chin. J. Biotech., 2017, 33(9): 1433−1465
27 Wang, Minlong #; Rui, Peng#; Liu, Caixiu; Du, Ying; Qin, Peiwen; Qi, Zhiqiu; Ji, Mingshan; Li, Xinghai*; Cui, Zi-Ning*. Design, synthesis and fungicidal activity of 2-substituted phenyl-2-oxo, 2-hydroxyl and 2-acyloxy ethylsulfonamides, Molecules, 2017, 22(5), 738.
28 Li, Ya-Sheng#; Hu, De-Kun#; Zhao, Dong-Sheng#; Liu, Xing-Yu; Jin, Hong-Wei; Song, Gao-Peng*; Cui, Zi-Ning*; Zhang, Lian-Hui. Design, Synthesis and Biological Evaluation of 2,4-Disubstituted Oxazole Derivatives as Potential PDE4 Inhibitors. Bioorg. Med. Chem., 2017, 25(6), 1852-1859.
29 Liu, Chun-Hui; Chen, Xiao-Yuan; Qin, Pei-Wen; Qi, Zhi-Qiu; Ji, Ming-Shan; Liu, Xing-Yu; Babu, P. Vijaya; Li, Xing-Hai*; Cui, Zi-Ning*. Synthesis, Fungicidal Activity, and Structure Activity Relationship of β-Acylaminocycloalkylsulfonamides against Botrytis cinerea, Sci. Rep., 2017, 7, 42096.
30 Liu, Caixiu#; Yan, Xiaojing#; Wang, Minlong; Qin, Peiwen; Qi, Zhiqiu; Ji, Mingshan; Liu, Xingyu; Babu, P. Vijaya; Li, Xinghai*; Cui, Zi-Ning*. Design, synthesis and fungicidal activity of novel 2-substituted aminocycloalkylsulfonamides. Bioorg. Med. Chem. Lett., 2017, 27(2), 271-276.
31 Fan, Susu; Tian, Fang*; Li, Jianyu; Chen, Huamin; Yang, Fenghuan; Hutchins, William; Yuan, Xiaochen; Cui, Zi-Ning; Yang, Ching-Hong*; He, Chenyang. Identification of phenolic compounds that suppress the virulence of Xanthomonas oryzae on rice via the type III secretion system. Mol. Plant Pathol., 2017, 18(4), 555-568.
32 Zhou, Jia-Nuan#; Zhang, Hai-Bao#; Lv, Ming-Fa; Chen, Yu-Fan; Liao, Li-Sheng; Cheng, Ying-Ying; Liu, Shi-Yin; Chen, Shao-Hua; He, Fei; Cui, Zi-Ning; Jiang, Zi-De; Chang, Changqing*; Zhang, Lian-Hui*. SlyA regulates phytotoxin production and virulence in Dickeya zeae EC1. Mol. Plant Pathol., 2016, 17(9), 1398-1408.
33 Wang, Chao; Liu, Xiaoling; Wang, Jing; Zhou, Jianuan; Cui, Zi-Ning; Zhang, Lian-Hui*. Design and characterization of a polyamine derivative inhibiting the expression of type III secretion system in Pseudomonas aeruginosa. Sci. Rep., 2016, 6, 30949.
34 Song, Gaopeng#; Li, Sumei#; Lei, Zhiwei; Li, Yibin; Li, Junhua; Liao, Yixian; Cui, Zi-Ning*. Synthesis and biological evaluation of acylated oligorhamnoside derivatives structurally related to mezzettiaside-6 with cytotoxic activity. Org. Biomol. Chem., 2016, 14(28), 6691-6702(cover paper).
35 Li, Ya-Sheng#; Tian, Hao#; Zhao, Dongsheng#; Hu, De-Kun; Jin Hongwei; Song, Gaopeng*; Cui, Zi-Ning*. Synthesis and Bioactivity of Pyrazole and Triazole Derivatives as Potential PDE4 Inhibitors. Bioorg. Med. Chem. Lett., 2016, 26(15), 3632-3635.
36 Wang, Chao; Liu, Xiaoling; Wang, Jing; Cui, Zining; Zhang, Lian-Hui*. Design and characterization of a polyamine derivative inhibiting the expression of type III secretion system in Pseudomonas aeruginosa. Sci. Rep., 2016, 6, 30949.
37 Fan, Susu; Tian, Fang; Li, Jianyu; Chen, Huamin; Yang, Fenghuan; Hutchins, William; Yuan, Xiaochen; Yang, Cui Zi-Ning, Ching-Hong Yang*; He, Chenyang. Identification of phenolic compounds that suppress the virulence of Xanthomonas oryzae on rice via the type III secretion system. Mol. Plant Pathol., 2016, 17(9), 1398-1408.
38 Liu, Chunhui; Cui, Zi-Ning*; Yan, Xiaojing; Qi, Zhiqiu; Ji,Mingshan; Li, Xinghai*. Synthesis, Fungicidal Activity and Mode of Action of 4-Phenyl-6-trifluoromethyl-2- aminopyrimidines against Botrytis cinerea. Molecules, 2016, 21(7), 828.
39 Song, Gao-Peng #; Hu, De-Kun #; Tian, Hao#; Li, Ya-Sheng; Cao, Yun-Shen; Jin, Hong-Wei*; Cui, Zi-Ning*. Synthesis and Larvicidal Activity of Novel Thenoylhydrazide Derivatives. Sci. Rep., 2016, 6, 22977.
40 Song, Gaopeng#; Li, Jianzuo#; Tian, Hao; Li, Yasheng; Hu, Dekun; Li, Ying*; Cui, Zi-Ning*. Synthesis and Antitumor Activity of Novel N-Benzoyl-N'-substituted Pyrimidinyl (Thio)semicarbazide Derivatives. Lett. Drug Des. Discov., 2016, 13(4), 329-334.
41 Cui, Zi-Ning*; Li, Ya-Sheng; Hu, De-Kun; Tian, Hao; Jiang, Jia-Zhen; Wang, Yuan; Yan, Xiao-Jing*. Synthesis and fungicidal activity of novel 2,5-disubstituted-1,3,4- thiadiazole derivatives containing 5-phenyl-2-furan, Sci. Rep., 2016, 6, 20204.
42 Song, Gaopeng; Zhao, Dongsheng; Hu, Dekun; Li, Yasheng; Jin, Hongwei; Cui, Zi-Ning*. Design, Synthesis and Biological Evaluation of NovelTetrahydroisoquinoline Derivatives as Potential PDE4 Inhibitors, Bioorg. Med. Chem. Lett., 2015, 25(20), 4610-4614.
43 Song, Gao-peng; Li, Su-mei; Si, Hong-zong; Li, Yi-bin; Li, Ya-sheng; Fan, Ji-hong; Liang, Qian-qian; He, Hui-bing; Ye, Han-ming; Cui, Zi-Ning*. Synthesis and Bioactivity of Novel Xanthone and Thioxanthone L-Rhamnopyranosides, RSC Adv., 2015, 5(45), 36092-36103.
44 Li, Chengkun; Jiang, Lin; Wang, Yue; Wan, Fuxian; Zhang, Peizhi; Li, Ying; Cui, Zi-Ning*. Design, Synthesis and Biological Activities of N-(Substituted benzoyl)-N′-(5-methoxyl-2- methylsulfanylpyrimidin-4-amino) (thio) Ureas, Chin. J. Org. Chem., 2014, 34(11), 2296-2303.
45 Cui, Zining*; Ito, Jun; Dohi, Hirofumi; Amemiya, Yoshimiki; Nishida, Yoshihiro. Molecular Design and Synthesis of Novel Salicyl Glycoconjugates as Elicitors against Plant Diseases, PLOS One, 2014, 9(9), e108338.
46 Cui, Zining*; Li, Xinghai; Tian, Fang; Yan, Xiaojing. Synthesis and Bioactivity of 5-Substituted-2-furoyl Diacylhydazide Derivatives with Aliphatic Chain, Int. J. Mol. Sci., 2014, 15(5), 8941-8958.
47 Cui, Zining*; Su, Hang; Jiang, Jiazhen; Yang, Xinling; Nishida, Yoshihiro. Design, Synthesis and Bioactivity of N-Glycosyl-N'-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives, Int. J. Mol. Sci., 2014, 15(4), 6741-6756
48 Cui, Zining*; Liang, Zhibin; Tian, Fang; Liu, Shiyin; Yan, Xiaojing. Synthesis and Bioactivity of Novel Pyridazin-3(2H)-one Derivatives Containing 5-Phenyl-2-furan (I), Chin. J. Pestic. Sci., 2014, 16(3), 252-258.
49 Cui, Zining*; Tian, Fang; Liang, Zhibin; Liu, Shiyin; Yan, Xiaojing. Synthesis and Bioactivity of Novel Pyridazin-3(2H)-one Derivatives Containing 5-Phenyl-2-furan (II), Chin. J. Pestic. Sci., 2014, 16(4), 394-399.
50 Cui, Zining*; Li, Xing-Hai; Nishida, Yoshihiro. Synthesis and Bioactivity of Novel Carvacrol and Thymol Derivatives Containing 5-Phenyl-2-furan, Lett. Drug Des. Discov., 2014, 11(7), 877-885.
51 Li, Xing-Hai*; Pan, Qiang; Cui, Zi-Ning*; Ji, Ming-Shan; Qi, Zhi-Qiu. Synthesis and Fungicidal Activity of N-(2,4,5-trichlorophenyl)-2-Oxo- and 2-Hydroxycycloalkylsulfon amides, Lett. Drug Des. Discov., 2013, 10(4), 353-359.
52 Li, Xing-Hai#; Cui, Zi-Ning# (first co-author); Chen, Xiao-Yuan; Wu, De-Cai; Qi, Zhi-Qiu; Ji, Ming-Shan*. Synthesis of 2-Acyloxycyclohexylsulfonamides and Evaluation on Their Fungicidal Activity, Int. J. Mol. Sci., 2013, 14(11), 22544-22557.
53 Cui, Zi-Ning; Shi, Yan-Xia; Zhang, Li; Ling, Yun; Li, Bao-Ju; Nishida, Yoshihiro; Yang, Xin-Ling*. Synthesis and Fungicidal Activity of Novel 2, 5-Disubstituted-1, 3, 4-oxadiazole Derivatives, J. Agric. Food Chem., 2012, 60(47), 11649−11656.
54 Cui, Zi-Ning; Shi, Yan-Xia; Cui, Jing-Rong; Ling, Yun; Li, Bao-Ju; Yang, Xin-Ling*. Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan. Chem. Biol. Drug Des., 2012, 79(1), 121-127.
55 Cui, Zi-Ning; Yang, Xin-Ling; Shi, Yan-Xia; Uzawa, Hirotaka; Cui, Jing-Rong; Dohi, Hirofumi; Nishida, Yoshihiro*. Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety. Bioorg. Med. Chem. Lett., 2011, 21(23), 7193-7196.
56 Cui, Zi-Ning; Zhang, Li; Huang, Juan; Yang, Xin-Ling; Ling, Yun*. Synthesis and Bioactivity of Novel N,N′-Diacylhydrazine Derivatives Containing Furan(III). Chin. J. Chem., 2010, 28(7), 1257-1266.
57 Cui, Zi-Ning; Zhang, Li; Huang, Juan; Ling, Yun; Yang, Xin-Ling*. Synthesis, Insecticidal Activity and 3D-QSAR Studies on Diacylhydrazine Derivatives Containing Furan. Chin. J. Org. Chem., 2010, 30(10), 1482-1491.
58 Cui, Zi-Ning; Ling, Yun; Li, Bao-Ju; Li, Yong-Qiang; Rui, Chang-Hui; Cui, Jing-Rong; Shi, Yan-Xia; Yang, Xin-Ling*. Synthesis and Bioactivity of N-benzoyl-N'-[5-(2'- substituted phenyl)-2-furoyl] semicarbazide Derivatives. Molecules, 2010, 15(6), 4267-4282.
59 Cui, Zi-Ning; Li, Ying; Ling, Yun; Huang, Juan; Cui, Jing-Rong; Wang, Rui-Qing; Yang, Xin-Ling*. New Class of Potent Antitumor Acylhydrazone Derivatives Containing Furan. Eur. J. Med. Chem., 2010, 45(12), 5576-5584.
60 Cui, Zi-Ning; Ma, Yong-Qiang; Ling, Yun; Yang, Xin-Ling*. Crystal Structure of Hexa-2-chloro-4-oxo- tetrakis [(1, 4-dioxane-O4) copper(II)]. Analytical Sciences-X-ray Structure Analysis Online, 2009, 25(7), 79-80.
61 Cui, Zi-Ning; Huang, Juan; Li, Ying; Ling, Yun; Yang, Xin-Ling*; Chen, Fu-Heng. Synthesis and Bioactivity of Novel N,N′-Diacylhydrazine Derivatives Containing Furan(I). Chin. J. Chem., 2008, 26(5), 916-922.
62 Cui, Zi-Ning; Zhang, Li; Huang, Juan; Li, Ying; Ling, Yun; Yang, Xin-Ling*. 3D-QSAR Studies on Diacylurea Derivatives Containing Furan Moiety. Acta Chim. Sinica, 2008, 66(12), 1417-1423.
63 Cui, Zi-Ning; Wang, Zhen; Li, Ying; Zhou, Xin-Yu; Ling, Yun; Yang, Xin-Ling*. Synthesis and Insecticidal Activity of Diacylhydrazine Containing Furan. Chin. J. Org. Chem., 2007, 27(10):1300-1304.
64 Cui, Zi-Ning; Yang, Lin; Li, Xi-Chen; Wang, Zhen; Yang, Xin-Ling*. Progress in the Study on the Synthesis and the Activities as Insect Growth Regulators of 2, 5-Disubstituted 1, 3, 4- Oxadiazoles. Chin. J. Org. Chem., 2006, 26(12), 1647-1656.
科研创新
已授权(8项):
1. 崔紫宁,向绪稳,陶辉,姜珊,张炼辉。一种氰基亚胺噻唑烷呋喃甲酰胺类化合物及其制备方法和应用。ZL 201710846135.3, 2020-12-29。
2. 崔紫宁,陶辉,田浩,向绪稳,姜珊,张炼辉。1,3,4-噻二唑类化合物在防治水稻白叶枯病中的应用。中国发明专利, ZL 201710845900.X, 2020-10-23。
3. 崔紫宁,李亚胜,胡德坤,田浩,刘星宇,宋高鹏。一种含噁唑环2,4-二取代吡唑类化合物及其制备方法和应用。中国发明专利, ZL 201610885307.3, 2019-10-29。
4. 崔紫宁,胡德坤,田浩,李亚胜,宋高鹏,刘星宇。N’-5-(取代苯基)-2-呋喃甲酰基-5-丙基-1H-吡唑-3-甲酸乙酯类化合物及其制备方法与应用。中国发明专利, ZL 201610383248.X, 2018-8-7。
5. 崔紫宁,田浩,胡德坤,李亚胜,宋高鹏,刘星宇。S-(5-取代-1,3,4-噻二唑)-(5-取代苯基)-2-呋喃硫代甲酸酯类化合物及其制备方法与应用。中国发明专利, ZL 201610382784.8, 2018-6-19。
6. 崔紫宁,陈昱帆,程莹莹,周佳暖,刘诗胤,陈少华。含呋喃环2,5-二取代-1,3,4-噻二唑类化合物在制备致病疫霉菌抑菌剂中的应用,中国发明专利。ZL 201310631983.4, 2016-3-30。
7. 崔紫宁,程莹莹,刘诗胤,陈昱帆,周佳暖,陈少华。一种含呋喃环2, 5-二取代-1, 3, 4-噻二唑类化合物及其制备方法和应用,中国发明专利。ZL 201310629477.1, 2015-10-28。
8. 崔紫宁,周佳暖,刘诗胤,程莹莹,陈少华。一种苯基取代噻吩甲酰肼类化合物及其制备方法和应用,中国发明专利。ZL 201310574554.8, 2015-06-17。

审查中(12项):
1 崔紫宁,李司丞,高冬倪,古景文,贺露露。苯并噻唑化合物作为群体感应抑制剂在治疗细菌病害中的应用。申请号:202010776506.7, 申请日:2020-8-5;申请公布号:CN112043697A;申请公布日:2020-12-08。
2 崔紫宁,邵将,贺露露,古景文,高冬倪。肉桂酸甲酯作为群体感应抑制剂及其在治疗细菌病害中的应用。申请号:202010776777.2, 申请日:2020-08-5;申请公布号:CN112042648A;申请公布日:2020-12-08。
3 王鸿,崔紫宁,魏斌,周涛顺。氰基亚胺噻唑烷呋喃甲酰胺类化合物在制备β-葡萄糖醛酸苷酶抑制剂中的应用。申请号:2020104055032, 申请日:2020-05-14;申请公布号:CN111419843A;申请公布日:2020-07-17
4 崔紫宁,何敏,姜珊,李宇豪,陈恺宏,向绪稳。(S)-1,3-噻唑苯基呋喃硫代甲酸酯类化合物的制备方法和应用。申请号:201910507402.3, 申请日:2019-06-12;申请公布号:CN110294749A;申请公布日:2019-10-1。
5 崔紫宁,何敏,姜珊,李宇豪,向绪稳。一种含1,2,3,4-四氮唑的呋喃硫代甲酸酯类化合物的制备方法和应用。申请号:2019104732016,.申请日:2019-5-31;申请公布号:CN110183428A;申请公布日:2019-08-30。
6 崔紫宁,向绪稳,陶辉,姜珊,林以诺。苯丙烯酸化合物在预防和/或治疗植物病害中的应用。申请日:2018-11-28;申请公布号:CN109526961A;申请公布日:2019-03-29。
7 崔紫宁;陶辉;向绪稳;姜珊;艾哈迈德•瓦西姆。2-甲氧基苯丙酸化合物在预防和/或治疗植物病害中的应用。申请日:2018-11-28;申请公布号:CN109479878A;申请公布日:2019-03-19。
8 崔紫宁;姜珊;宋高鹏;李辉;向绪稳。β-硝基丙烯酸乙酯类化合物在预防和/或治疗植物病害中的应用。申请公布号:CN109503385A;申请公布日:2019-03-22。
9 崔紫宁;艾哈迈德•瓦西姆;向绪稳;宋高鹏;林以诺;李司丞。一种含噁唑环的2-氰基亚氨基噻唑烷类化合物及其制备方法和应用。申请公布号:CN109438434A;申请公布日:2019-03-08。
10 崔紫宁;陶辉;田浩;姜珊;向绪稳。一类取代苯基呋喃-2-巯基噻唑啉甲酮类化合物及其制备方法和应用。申请公布号:CN CN109265452A;申请公布日:2019-01-25。
11 崔紫宁,向绪稳,何敏,吴伟生。一种1,3,4-噻(噁)二唑-吩嗪甲酰胺类化合物的制备方法和应用。申请公布号:CN 107880035 A;申请公布日:2018-04-06。
12 崔紫宁,胡德坤,宋高鹏,向绪稳,陶辉,刘星宇。一种取代苯基呋喃甲酰基吡唑类化合物及其制备方法和应用。CN 107814791 A, 申请公布日:2018-03-20。
教学活动
《微生物次生代谢小分子研究方法》,《植物保护研究进展》,《高级植物病理学》
指导学生情况
指导3名硕士研究生获得优秀毕业生称号,并且研究论文被评为优秀毕业论文(李亚胜,姜珊,廖亦贤)。指导本科生获得省级大学生创新创业训练计划项目一项(李宇豪),校级项目两项(古景文,李司丞)。
我的团队
现有成员:郭巧巧(博士后),Muhammad Adnan(博士后),王鑫(助理),张昭圣(2020博士),何敏(2020硕士),邵将(2020硕士),贺露露(2019硕士),高冬倪(2019硕士),付晨(2019硕士),林以诺(2018硕士),李辉(2018硕士)。本科生:李司丞(2017级,植保丁颖),陈凯宏(2017级,植保丁颖),李宇豪(2017级,农学生物技术),谢志丽(2017级,植保),朱迪(2018级,植保),崔子岳(2018级,植保),李媛婧(2018级,植保),王冰茹(2018级,植保),陈日辉(2018级,食品),古景文(2018级,农学生物技术),李文龙(2019,农贸),陈彦(2019,植保),赖宏宇(2019,植保)。已毕业成员:李亚胜(2014硕士,优秀毕业生,浙江工业大学博士生),胡德坤(2015硕士,东阳光药业),田浩(2015硕士,南开大学博士生),向绪稳(2016硕士,东阳光药业),陶辉(2016硕士,中国农科院植保所博士生),姜珊(2017硕士,优秀毕业生,优秀毕业论文,CSC公派德国马普所),廖亦贤(2017硕士,优秀毕业生,优秀毕业论文,中国药科大学博士生)。本科生:何燕红(2012,制药),伍顺景(2012,制药),吴伟星(2012,制药),雷湘君(2012,植保),叶欣(2012,植保),阮晓红(2013,制药),杨冠欣(2013,制药),刘星宇(2014,植保),甘燕红(2014,制药),郭奕群(2014,制药),卢杰贤(2014,制药),何敏(2015,植保)。Wasim Ahmed(博士后)。