目录
更新日期:2019年9月22日
姓 名 张玲华 性 别
出生年月 1973年3月 籍贯 宁波
民 族 汉族 政治面貌 中共党员
最后学历 博士研究生 最后学位
技术职称 教授 导师类别 博导
行政职务 Email lhzhang@scau.edu.cn
工作单位 微生物学教研室 邮政编码
通讯地址
单位电话
个人主页
个人简介
张玲华,女,华南农业大学教授,博士生导师,广东省千百十培养对象。2006年至今已在Vaccine、 Molecular Immunology、Developmental and Comparative Immunology等国际知名期刊发表20余篇论文,累积影响因子118.998,8项发明专利授权。作为学科带头人,积极推动学院“211”学科建设,协助组织并顺利通过了生化与分子生物学广东省重点学科中期评估。此外还兼任广东省科技咨询专家、教育部“博士后基金”评审专家等。
工作经历
 2006/1 - 至今,华南农业大学,生命科学学院,教授
教育经历
 2007/9 - 2009/7,华南理工大学,发酵工程,博士,
 1996/9 - 1999/7,华南理工大学,发酵工程,硕士,
 1992/9 - 1996/7,华南理工大学,生物化工,学士
研究领域
微生物及免疫学
科研项目
获得国家基金,省攻关,省基金,市重点攻关项目等 多项项目支助。
发表论文
(1)Zhang S.X, Cai H.M., Cao D, Deng J.B., Jia J.H., Li J.Q., Ming F.P., Zhao P.J., Ma M.P., Liang Q.L., Zeng M., Zhang L.H.(张玲华)*. (2019) Recombinant plasmids containing CpG with porcine host defense peptides (PR-39/pBD-1) modulates the innate and adaptive intestinal immune responses (including maternal-derived) in piglets. Int. Immunopharmacol. 70, 467-476 (*通讯作者,2018SCI Impact factor, 3.118)
(2)Cai H.M., Deng J.B., Li J.Q., Ma M.P., Huang C, Zhao P, Ming F.P., Liang Q.Y., Jia J.H., Zhang S.X., Zeng M., Zhang, L.H. (张玲华)* (2019) Modulating the 3’ end-DNA and the fermentation process for enhanced production and biological activity of porcine interferon-gamma. PLoS ONE 14(3), e0214319. (*通讯作者,2018SCI Impact factor, 2.766)
(3)Yang, J., Cai, H.M., Liu, J., Z, Zeng. M., Cheng, Q.M, Zhang, L.H. (张玲华)*. (2018) Controlling AOX1 promoter strength in Pichia pastoris by manipulating poly (dA:dT) tracts. Scientific Reports, 8:1401-1412.(*通讯作者,2018 SCI Impact factor, 4.602)
(2)Cai, H.M., Chen, J.W., Liu, J., Ming, F.P., Lu, Z.P., Cheng, Q.M., Yang, J., Zhang, L.H. (张玲华)*. (2017) CRIP1, a novel immune-related protein, activated by Enterococcus faecalis in porcine gastrointestinal epithelial cells. Gene, 598, 84-96. (*通讯作者,2016 SCI Impact factor, 2.339)
(3)Yang, J., Lu, Z.P., Chen, J.W., Chu, P.P., Cheng, Q.M., Liu, J., Ming, F.P., Huang, C.Y., Xiao, A.J., Cai, H.M., Zhang, L.H. (张玲华)*. (2016) Effect of cooperation of chaperones and gene dosage on the expression of porcine PGLYRP-1 in Pichia pastoris. Applied Microbiology and Biotechnology, 100:5453–5465. (* 通讯作者, 2015 SCI Impact factor, 3.811)
(4)Cai, H.M., Kuang Z.S., Huang K.Y., Shi, J.Q., Zhao X.J., Chu, P.P., Huang, C.Y., Ming, F.P., Xia, F.G., Yang, J., Zhang, L.H. (张玲华)*. (2014) CpG oligodeoxynucleotide protect neonatal piglets from challenge with the enterotoxigenic E. coli , Veterinary Immunology and Immunopathology, 161, 66–76 (* 通讯作者2013 SCI Impact factor, 1.782)
(5)Ming, F.P., Yang, J., Chu, P.P., Ma, M.P., Shi, J.Q., Cai, H.M., 参与人, Li, H.Z., Jiang, Z.G., Wang, W.F., Zhang, S.Q., Zhang L.H.(张玲华)*. (2013) Immunization of Aged Pigs with Attenuated Pseudorabies Virus Vaccine Combined with CpG Oligodeoxynucleotide Restores Defective Th1 Immune Responses, PLOS ONE,  8(6), 65536-65536 (* 通讯作者,2013 SCI Impact factor, 4.092)
(6)Ma, M.P., Wang, L.L., Yang, J., Cai, H.M., Shi, J.Q., Huang, Z.F., Zhang, S.Q., Zhang L.H.(张玲华)*. (2012) Age-related impaired Th1 responses to PRV vaccine in vivo in aged pigs, Molecular Immunology, 52, 217-222 (* 通讯作者,2011 SCI Impact factor, 2.897)
(7)Yang, J., Mao, M.P., Huang Z.F., Zhang, S.Q., Chen, S.F., Li, H.Z., Jiang, Z.G., Cao, G.J., Cao, D., Wang, X.F., Zhang L.H.(张玲华)*. (2012)  Innate defence regulator peptide synergizes with CpG ODN for enhanced innate instestinal immune responses in neonate piglets. Int. Immunopharmacol. 12(2), 415–424 (*通讯作者,2011 SCI Impact factor, 2.325)
(8)Cao, D., Li, H.Z., Jiang, Z.G, Cheng, Q., Yang, Z.H., Xu, C.C., Cao, G.J., Zhang L.H.(张玲华)*. (2011) CpG oligodeoxynucleotide synergizes innate defense regulator peptide for enhancing the systemic and mucosal immune responses to pseudorabies attenuated virus vaccine in piglets in vivo.  Int. Immunopharmacol. 11, 748–754 (*通讯作者,2010 SCI Impact factor, 2.325)
(9)  Cao, D., Li, H.Z., Jiang, Z.G, Xu, C.C., Cheng, Q., Yang, Z.H., Cao, G.J., Zhang L.H.(张玲华)*. (2010) Synthetic innate defence regulator peptide enhances in vivo immunostimulatory effects of CpG-ODN in newborn piglets. Vaccine. 28, 6006–6013. (*通讯作者,2009 SCI Impact factor, 3.616)
(10)Cheng, Q., Xu, C.C., Zhang L.H.(张玲华)*, Li, J.Q., Cao, T., Zhang, M.R. (2010) Administered CpG Oligodeoxynucleotide Induces mRNA expression of CXC and CC Chemokines at the Intestinal Mucosa and PBMCs in Piglets. Int. Immunopharmacol. 10, 611-618 (*通讯作者, 2009 SCI Impact factor, 2.214)
(11)Cheng, Q., Jiang, Z.G.,  Xu, C.C., Li, H.Z., Cao, D., Yang, Z.H., Cao, G.J., Zhang L.H.(张玲华)* (2010)  CpG oligodeoxynucleotide promotes protective immunity in the enteric mucosa and suppresses enterotoxigenic E. coli in the weaning piglets. Int. Immunopharmacol.   10, 1249–1260 (*通讯作者, 2009 SCI Impact factor, 2.214)
(12)Zhang L.H.(张玲华)*, Tian, X.S., Zhou, F.Z. (2008a) In vivo oral administration effects of various oligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to pseudorabies attenuated virus vaccine in newborn piglets. Vaccine. 26, 224-233. (*通讯作者,2007 SCI Impact factor, 3.377)
(13)Zhang L.H.(张玲华)*, Zhang, M.R., Li, J.Q., Cao, T., Tian, X.S., Zhou, F.Z. (2008b) Enhancement of mucosal immune responses by intranasal co-delivery of Newcastle disease vaccine plus CpG oligonucleotide in SPF chickens in vivo.  Research in Veterinary Science. 85,  495–502.  (2007 SCI Impact factor, 1.274)
(14)Zhang L.H.(张玲华)*, Tian, X.S., Zhou, F.Z. (2007a)  In vivo immunostimulatory effects of CpG ODN in newborn piglets. Molecular Immunology. 44, 1238–1244. (*通讯作者,2006 SCI Impact factor, 4.768)
(15)Zhang L.H.(张玲华)*, Tian, X.S., Zhou, F.Z. (2007b) In vivo effects of oligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to swine streptococcic septicemia vaccine in weaned piglets. Molecular Immunology. 44, 1141–1149. (*通讯作者,2006 SCI Impact factor, 4.768)
(16)Zhang L.H.(张玲华)*, Tian, X.S., Zhou, F.Z. (2007c) Vaccination with porcine reproductive and respiratory syndrome killed virus vaccine and immunostimulatory oligodeoxynucleotides induces specific immunity in piglets. Vaccine. 25, 1735–1742. (*通讯作者,2006 SCI Impact factor, 3.159)
(17)Zhang L.H.(张玲华)*, Tian, X.S., Zhou, F.Z. (2007d) Vaccination with Newcastle disease vaccine and CpG oligodeoxynucleotides induces specific immunity and protection against Newcastle disease virus in SPF chicken. Veterinary Immunology and Immunopathology. 115, 216–222. (*通讯作者,2006 SCI Impact factor, 1.994)
(18)Zhang L.H.(张玲华)*, Tian, X.S., Zhou, F.Z. (2007e) Intranasal administration of CpG oligonucleotides induces mucosal and systemic Type 1 immune responses and adjuvant activity to porcine reproductive and respiratory syndrome killed virus vaccine in piglets in vivo. International Immunopharmacology. 7(13), 1732–1740. (*通讯作者, 2006 SCI Impact factor, 2.157)
(19)Zhang L.H.(张玲华)*, Tian, X.S., Zhou, F.Z. (2007f) CpG oligodeoxynucleotides augment the immune responses of piglets to swine Pasteurella multocida living vaccine in vivo. Research in Veterinary Science. 83(2),171-181. (2006 SCI Impact factor, 1.258)
(20)Zhang L.H.(张玲华)*, Guo, Y., Tian, X.S., Zhou, F.Z. (2006a) Co-administration of porcine-specific CpG oligodeoxynucleotide enhances the immune responses to pseudorabies attenuated virus vaccine in newborn piglets in vivo. Developmental and Comparative Immunology. 30(6), 589-596. (*通讯作者,2005 SCI Impact factor, 3.261)
(21)Zhang L.H.(张玲华)*, Tian, X.S., Guo, Y., Zhou, F.Z. (2006b) Effects of CpG ODN on CD4+ and CD8+ T subpopulations in the immune response to porcine reproductive and respiratory syndrome killed virus vaccine. Vaccine. 24(11), 1874-1879 . (*通讯作者,2005 SCI Impact factor, 2.822)
(22)Zhang L.H.(张玲华)*, Tian, X.S., Zhou, F.Z. (2006c) The efficacy of CpG oligodinucleotides, in combination with conventional adjuvants, as immunological adjuvants to swine streptococcic septicemia vaccine in piglets in vivo. International Immunopharmacology. 6(8), 1267-1276. (*通讯作者,2005 SCI Impact factor, 2.008)
(23)Zhang L.H.(张玲华)*, Tian, X.S., Zhou, F.Z. (2006d) In vivo effects of oligodeoxynucleotides containing synthetic immunostimulatory motifs in weaned piglets. International Immunopharmacology. 6(10),1623-1631. (*通讯作者,2005 SCI Impact factor, 2.008)
(24)Zhang L.H.(张玲华)*, Guo, Y., Tian, X.S., Zhou, F.Z. (2006e) CpG oligodinucleotides induce strong humoral and cellular responses to swine streptococcic septicemia vaccine in piglets in vivo. International Immunopharmacology. 6(3), 342-350. (*通讯作者,2005 SCI Impact factor, 2.008)
(25)Zhang L.H.(张玲华)*, Tian, X.S., Guo, Y., Zhou, F.Z. (2006f) The effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of the newborn piglets inoculated with pseudorabies attenuated vaccine. Research in Veterinary Science. 80, 281-286. (2005 SCI Impact factor, 1.106)
科研创新
(1)张玲华,田兴山,邝哲师,陈薇,李健雄,有益微生物制剂稳定化预处理工艺,2006.12,中国,ZL200310117512.8
(2)邝哲师,田兴山,张玲华,陈薇,李健雄,“有益微生物制剂稳定化后处理工艺”, 2006.8,中国, ZL200310117511.3
(3)邝哲师,张玲华,徐志宏,“一种微生物转化菠萝渣为生物饲料的制备方法”, 2008.1,中国, ZL200610033024.2
(4)张玲华,李华周,姜增固。“一种高效CpG制剂及其制备方法和应用”, 2014.6,中国,ZL201210090979.7
(5)张玲华,邝哲师,蔡海明,赵祥杰,楚品品,叶明强,“一种高效提高枯草芽孢杆菌出芽率的方法”,专利号:ZL201410162370.5
(6)张玲华,蔡海明,马苗鹏,周洁安,“一种高效抗炎性PB ODN序列及其应用”,专利号:ZL 20151043403.5
(7)张玲华,马苗鹏,杨军,“一种嗜酸乳酸杆菌与醋酸杆菌混合发酵的方法”,专利号:ZL201510335715.7
(8)江学斌,张玲华,胡位荣,马苗鹏,黄瀚威,“一种高效降低水体COD沼泽红假单胞菌的培养基”专利号:ZL201610026084.5
教学活动
指导大学生国家级大创项目1项,省级3项。