目录
更新日期:2020年6月5日
姓 名 杨杰 性 别
出生年月 1987年6月 籍贯 湖南安乡县
民 族 汉族 政治面貌
最后学历 博士研究生 最后学位 农学博士
技术职称 副研究员 导师类别 硕导
行政职务 Email jieyang@scau.edu.cn
工作单位 动物科学学院国家生猪种业工程技术研究中心 邮政编码 510642
通讯地址 广东省广州市天河区五山路483号华南农业大学动物科学学院
单位电话 02085280369
个人主页
个人简介
杨杰,男,博士,副研究员,硕士生导师(学硕、专硕)。江西省优秀博士论文获得者、广州市“珠江科技新星”、美国密歇根州立大学访问学者。主要致力于猪复杂经济性状的遗传解析工作,先后主持国家自然科学基金面上项目、国家自然科学基金青年基金、广东省自然科学基金重点项目、广东省科技计划、广东省自然科学基金、华南农业大学青年科技人才专项基金等项目;获得授权国家发明专利15项,并在PLoS Genetics、Frontiers in Genetics、BMC Genomics和Frontiers in Microbiology等国际知名学术期刊发表学术论文30余篇。
工作经历
2019.01 – 至今:华南农业大学,国家生猪种业工程技术研究中心,副研究员;
2017.02 – 2018.12:华南农业大学,国家生猪种业工程技术研究中心,青年副教授;
2015.07 – 2017.02:华南农业大学,国家生猪种业工程技术研究中心,助理研究员。
教育经历
2017/08 – 2018/08,Michigan State University,Department of Animal Science,访问学者;
2009/09 – 2015/06,江西农业大学,猪遗传改良与养殖技术国家重点实验室,动物遗传育种与繁殖,硕士、博士;
2005/09 – 2009/06,江西农业大学,动物科学技术学院,动物科学,学士。
获奖、荣誉称号
2019年:第20次全国动物遗传育种大会“优秀论文奖”;
2018年:广州市“珠江科技新星”;
2017年:江西省优秀博士学位论文;
2014年:获得由教育部颁发的“博士研究生国家奖学金”;
2014年:应邀在“第34届国际动物遗传育种大会”做学术报告,并同时获得该大会的“杰出墙报奖”。
社会、学会及学术兼职
国家自然科学基金、广东省自然科学基金同行评审专家。
研究领域
(1)猪重要经济性状的遗传解析。采用整合基因组、转录组、蛋白质组及表观遗传学的多组学研究手段,结合不同的统计分析模型,鉴别影响猪重要经济性状的关键基因,并对关键基因开展功能验证,进而结合温氏集团进行相应的分子育种及专门化品系培育;
(2)瘦肉型猪先天性遗传缺陷的遗传机制研究。基于温氏集团大规模种猪样本素材,对主流瘦肉型种猪20余种遗传缺陷表型进行精确分类,采用多组学手段鉴别其主效基因及关键突变位点,进而结合分子育种手段,逐步剔除瘦肉型种猪中危害较大的遗传缺陷,提升养猪生产效率;
(3)猪肠道微生物影响重要经济表型的遗传机制。采用宏基因组测序技术及16S rRNA扩增子技术,鉴别影响猪重要经济性状或复杂遗传疾病性状的标志微生物,综合多组学研究手段,对标志微生物开展下游功能研究。
科研项目
1. 国家自然科学基金面上项目,31972540,鉴别猪13号染色体影响悬蹄过度生长的目的基因及其关键突变,2020/01/01-2023/12/31,59万元,在研,主持(1/8);
2. 广东省自然科学基金重点项目,2018B030315007,瘦肉型猪主要遗传缺陷基础性调查及遗传机制研究,2018/05/01-2021/04/31,50万元,在研,主持(1/10);
3. 广州市珠江科技新星项目,201906010011,大白种猪先天性趾蹄疾患的遗传机制研究,2019/04/01-2021/03/31,30万元,在研,主持(1/6);
4. 国家自然科学基金青年基金,31601912,猪8号染色体影响肌内脂肪含量QTL的遗传解析,2017/01/01-2019/12/31,20万元,已结题,主持(1/7);
5. 广东省科技计划项目,2017B020201012,杜洛克种猪肉质性状遗传改良及专门化品系培育,2017/01/01-2019/12/31,50万元,已结题,主持(1/7);
6. 广东省自然科学基金项目,2016A030310447,利用系统遗传学分析方法鉴别影响猪饲料转化效率的主效基因,2016/06/01-2019/06/01,10万元,已结题,主持(1/7);
7. 华南农业大学青年科技人才培育专项基金,2016-6,影响瘦肉型种猪肌内脂肪含量功能基因的挖掘,2016/06/01-2017/12/31,20万元,已结题,主持(1/1);
8. 温氏科研基金项目,温氏节粮型父系杜洛克公猪的分子标记选育及应用,2016/01/01-2018/12/31,15万元,已结题,主持(1/7)。
发表论文
(一)英文论文
30. Zhanwei Zhuang, Rongrong Ding, Longlong Peng, Jie Wu, Yong Ye, Shenping Zhou, Xingwang Wang, Jianping Quan, Enqin Zheng, Gengyuan Cai, Wen Huang, Jie Yang@, Zhenfang Wu@.(2020) Genome-wide Association Analyses Identify Known and Novel Loci for Teat Number in Duroc Pigs using Single-Locus and Multi-Locus Models. BMC Genomics, 21:344 (@corresponding authors, IF2018=3.501;生物II区)
29. Cineng Xu, Xingwang Wang, Zhanwei Zhuang, Jie Wu, Shenping Zhou, Jianping Quan, Rongrong Ding, Yong Ye, Longlong Peng, Zhenfang Wu, Enqin Zheng@, Jie Yang@.(2020) A Transcriptome Analysis Reveals that Hepatic Glycolysis and Lipid Synthesis Are Negatively Associated with Feed Efficiency in DLY Pigs. Scientific Reports. DOI: 10.1038/s41598-020-66988-6 (@corresponding authors, IF2018=4.011;综合III区)
28. Jianping Quan, Zhenfang Wu, Yong Ye, Longlong Peng, Jie Wu, Donglin Ruan, Yibin Qiu, Rongrong Ding, Xingwang Wang, Enqin Zheng, Gengyuan Cai, Wen Huang@, Jie Yang@.(2020) Metagenomic characterization of intestinal regions in pigs with contrasting feed efficiency. Frontiers in Microbiology.DOI: 10.3389/fmicb.2020.00032 (@corresponding authors, IF2018=4.259;生物II区)
27. Zhanwei Zhuang, Lingyang Xu, Jie Yang, Huijiang Gao, Lupei Zhang, Xue Gao, Junya Li, Bo Zhu. (2020) Weighted Single-Step Genome-Wide Association Study for Growth Traits in Chinese Simmental Beef Cattle. Genes. DOI:10.3390/genes11020189 (IF2018=3.331;生物III区)
26. Jie Wu, Xingwang Wang, Rongrong Ding, Jianping Quan, Yong Ye, Ting Gu, Zheng Xu, Enqin Zheng, Gengyuan Cai, Zhenfang Wu, Ming Yang@, Jie Yang@.(2020) Identification of Important Proteins and Pathways Affecting Feed Efficiency in DLY Pigs by iTRAQ-Based Proteomic Analysis. Animals, 10, 189; DOI:10.3390/ani10020189 (@corresponding authors, IF2018=1.832;农林科学III区)
25. Xingwang Wang, Shaoyun Li, Jie Wu, Rongrong Ding, Jianping Quan, Enqin Zheng, Jie Yang@, Zhenfang Wu@.(2019) A transcriptome analysis identifies biological pathways and candidate genes for feed efficiency in DLY pigs. Genes. DOI:10.3390/genes10090725 (@corresponding authors, IF2018=3.331;生物III区)
24. Rongrong Ding, Ming Yang, Jianping Quan, Shaoyun Li, Zhanwei Zhuang, ShenPing Zhou, Enqin Zheng, Linjun Hong, Zicong Li, Gengyuan Cai, Wen Huang, Zhenfang Wu@, Jie Yang@.(2019) Single-locus and multi-locus genome-wide association studies for intramuscular fat in Duroc pigs. Frontiers in Genetics.DOI: 10.3389/fgene.2019.00619 (@corresponding authors, IF2018=3.517;生物II区)
23. Linjun Hong, Ting Gu, Yanjuan He, Chen Zhou, Qun Hu, Wang Xingwang, Enqin Zheng, Sixiu Huang, Zheng Xu, Jie Yang, Huaqiang Yang, Zicong Li, Gengyuan Cai, and Zhenfang Wu.(2019) Genome-Wide Analysis of Circular Rnas Mediated Cerna Regulation in Porcine Embryonic Muscle Development, Frontiers in Cell and Developmental Biology, 7:289. (IF2018=5.206;生物II区)
22. Xianxian Liu, Lisheng Zhou, Xianhua Xie, Zhongzi Wu, Xinwei Xiong, Zhiyan Zhang, Jie Yang, Shijun Xiao, Mengqing Zhou,Junwu Ma, Lusheng Huang.(2019) Muscle glycogen level and occurrence of acid meat in commercial hybrid pigs are regulated by two low-frequency causal variants with large effects and multiple common variants with small effects. Genetics Selection Evolution. 23;51(1):46. (IF2018=3.094;生物III区).
21. Zhanwei Zhuang, Shaoyun Li, Rongrong Ding, Ming Yang, Enqin Zheng, Huaqiang Yang, Ting Gu, Zheng Xu, Gengyuan Cai, Zhenfang Wu@, Jie Yang@.(2019) Meta-analysis of genome-wide association studies for loin muscle area and loin muscle depth in two Duroc pig populations. PLoS One. DOI: 10.1371/journal.pone.0218263 (@corresponding authors, IF2018=2.776;生物III区)
20. Ting Gu, Junsong Shi, Lvhua Luo, Zicong Li, Jie Yang, Gengyuan Cai, Enqin Zheng, Linjun Hong, Zhenfang Wu.(2019) Study on hematological and biochemical characters of cloned duroc pigs and their progeny. Animals, 9(11), 912; DOI: 10.3390/ani9110912 (IF2018=1.832;农林科学III区)
19. Jianping Quan, Gengyuan Cai, Ming Yang, Zhonghua Zeng, Rongrong Ding, Wang Xingwang, Zhanwei Zhuang, Shenping Zhou, Shaoyun Li, Huaqiang Yang, Zicong Li, Enqin Zheng, Wen Huang, Jie Yang@, Zhenfang Wu@.(2019) Exploring the Fecal Microbial Composition and Metagenomic Functional Capacities Associated with Feed Efficiency in Commercial DLY Pigs. Frontiers in Microbiology.DOI: 10.3389/fmicb.2019.00052 (@corresponding authors, IF2018=4.259;生物II区)
18. Rongrong Ding, Ming Yang, Jianping Quan, Shaoyun Li, Zhanwei Zhuang, ShenPing Zhou, Enqin Zheng, Linjun Hong, Zicong Li, Gengyuan Cai, Wen Huang, Zhenfang Wu@, Jie Yang@.(2019) Single-locus and multi-locus genome-wide association studies for intramuscular fat in Duroc pigs. PAG XXVII - Plant & Animal Genome Conference, Santiago, United States, 2019.01.11-2019.01.16 (@corresponding authors)
17. Rongrong Ding, Ming Yang, Xingwang Wang, Jianping Quan, Zhanwei Zhuang, Shenping Zhou, Shaoyun Li, Zheng Xu, Enqin Zheng, Gengyuan Cai, Dewu Liu, Wen Huang, Jie Yang@, Zhenfang Wu@.(2018) Genetic Architecture of Feeding Behavior and Feed Efficiency in a Duroc Pig Population. Frontiers in Genetics.DOI: 10.3389/fgene.2018.00220 (@corresponding authors, IF2018=3.517;生物II区)
16. Jianping Quan, Gengyuan Cai, Jian Ye, Ming Yang, Rongrong Ding, Xingwang Wang, Enqin Zheng, Disheng Fu, Shaoyun Li, Shenping Zhou, Dewu Liu, Jie Yang@, Zhenfang Wu@.(2018) A global comparison of the microbiome compositions of three gut locations in commercial pigs with extreme feed conversion ratios. Scientific Reports.DOI:10.1038/s41598-018-22692-0(@corresponding authors, IF2018=4.011;综合III区)
15. Jianping Quan, Rongrong Ding, Xingwang Wang, Ming Yang, Yang Yang, Enqin Zheng, Ting Gu, Gengyuan Cai, Zhenfang Wu, Dewu Liu@, Jie Yang@.(2018) Genome-wide association study reveals genetic loci and candidate genes for average daily gain in Duroc pigs. Asian-Australasian Journal of Animal Sciences; 31(4): 480-488.(@corresponding authors, IF2018=1.227;农林科学IV区)
14. Yanyu Duan, Hui Zhang, Zhen Zhang, Jun Gao, Jie Yang, Zhongping Wu, Yin Fan, Yuyun Xing, Lin Li, Shijun Xiao, Yong Hou, Jun Ren Corresponding address, Lusheng Huang.(2018) VRTN is Required for the Development of Thoracic Vertebrae in Mammals. International Journal of Biological Science; 14(6):667-681. doi:10.7150/ijbs.23815. (IF2018=4.067;生物II区).
13. Zicong Li, Zhimin Yue, Zheng Ao, Chengfa Zhao, Junsong Shi, Chengcheng Zhao, Fang Zeng, Gengyuan Cai, Enqin Zheng, Jie Yang, Ting Gu, Huaqiang Yang, Linjun Hong, Zheng Xu, Dewu Liu@, Zhenfang Wu@.(2018) Maternal dietary supplementation of arginine increases the ratio of total cloned piglets born to total transferred cloned embryos by improving the pregnancy rate of recipient sows. Animal reproduction science; 196, 211-218. (IF2018=1.817;农林科学III区).
12. Rongrong Ding, Jianping Quan, Ming Yang, Xingwang Wang, Enqin Zheng, Huaqiang Yang, Disheng Fu, Yang Yang, Linxue Yang, Zicong Li, Dewu Liu, Gengyuan Cai, Zhenfang Wu@, Jie Yang@.(2017) Genome-wide association analysis reveals genetic loci and candidate genes for feeding behavior and eating efficiency in Duroc boars. PLoS One 12(8): e0183244. (@corresponding authors, IF2017=2.766;生物III区).
11. Xingwang Wang, Rongrong Ding, Jianping Quan, Linxue Yang, Ming Yang, Enqin Zheng, Dewu Liu, Gengyuan Cai, Zhenfang Wu@, Jie Yang@. (2017) Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscular fat in Duroc pigs. Frontiers of Agricultural Science and Engineering. DOI: 10.15302/J-FASE-2017152. (@corresponding author)
10. Guoling Li, Xianwei Zhang, Cuili Zhong, Jianxin Mo, Rong Quan, Jie Yang, Dewu Liu, Zicong Li, Huaqiang Yang, Zhenfang Wu.(2017)Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells. Scientific Reports, doi:10.1038/s41598-017-09306-x. (IF2017=4.122;综合III区).
9. Yuanmei Guo, Hengqing Qiu, Shijun Xiao, Zhenfang Wu, Ming Yang, Jie Yang, Jun Ren, Lusheng Huang.(2017) A genome-wide association study identifies genomic loci associated with backfat thickness, carcass weight, and body weight in two commercial pig populations. Journal of applied genetics. DOI: 10.1007/s13353-017-0405-6. (IF2017=1.756;生物IV区).
8. Jie Yang, Lusheng Huang, Ming Yang, Yin Fan, Lin Li, Shaoming Fang, Wenjiang Deng, Leilei Cui, Zhen Zhang, Huashui Ai, Zhenfang Wu, Jun Gao, Jun Ren. (2016) Possible introgression of the VRTN mutation increasing vertebral number, carcass length and teat number from Chinese pigs into European pigs. Scientific Reports, 6, 19240. (IF2016=4.259;综合II区).
7. Lisheng Zhou, Jing Li, Jie Yang, Chenlong Liu, Xianhua Xie, Yuna He, Xianxian Liu, Wenshui Xin, Wanchang Zhang, Jun Ren, Lusheng Huang, Junwu Ma.(2016) Genome-wide mapping of copy number variations in commercial hybrid pigs using a high-density SNP Genotyping Array. Russian Journal of Genetics, 52(1): 85-92. (IF2016=0.55;生物IV区).
6. Huashui Ai, Xiaodong Fang, Bin Yang, Zhiyong Huang, Hao Chen, Likai Mao, Feng Zhang, Lu Zhang, Leilei Cui, Weiming He, Jie Yang, Xiaoming Yao, Lisheng Zhou, Lijuan Han, Jing Li, Silong Sun, Xianhua Xie, Boxian Lai, Ying Su, Yao Lu, Hui Yang, Tao Huang, Wenjiang Deng, Rasmus Nielsen, Jun Ren, Lusheng Huang. (2015) Adaption and possible interspacies introgression in pigs revealed by whole-genome sequencing. Nature Genetics 47, 217-225. (IF2015=31.616; 生物I区).
5. Xianxian Liu, Xinwei Xiong, Jie Yang, Lisheng Zhou, Bin Yang, Huashui Ai, Huanban Ma, Xianhua Xie, Yixuan Huang, Shaoming Fang, Shijun Xiao, Jun Ren, Junwu Ma, Lusheng Huang.(2015) Genome-wide association analyses for meat quality traits in Chinese Erhualian pigs and Western Duroc × (Landrace × Yorkshire) commercial population. Genetics Selection Evolution, 47(1): 1-11. (IF2016=2.895;生物III区).
4. Junwu Ma=, Jie Yang=, Lisheng Zhou, Jun Ren, Xianxian Liu, Hui Zhang, Bin Yang, Zhiyan Zhang, Huanban Ma, Xianhua Xie, Yuyun Xing, Yuanmei Guo, Lusheng Huang. (2014) A splice mutation in the PHKG1 gene causes high glycogen content and low meat quality in pig skeletal muscle. PLoS Genetics 10(10): e1004710. (=equal contribution;IF2014=8.167;生物I区;博士论文内容).
3. Jie Yang, Lisheng Zhou, Jun Ren, Xianxian Liu, Hui Zhang, Bin Yang, Zhiyan Zhang, Huanban Ma, Xianhua Xie, Yuyun Xing, Yuanmei Guo, Junwu Ma, Lusheng Huang, A splice mutation in the PHKG1 gene causes high glycogen content and low meat quality in pig skeletal muscle, The 34th International Society for Animal Genetics Conference, Xi'an, P.R. China, 2014.07.28-2014.08.01
2. Xinwei Xiong, Xianxian Liu, Lisheng Zhou, Jie Yang, Bin Yang, Huanban Ma, Xianhua Xie, Yixuan Huang, Shaoming Fang, Shijun Xiao, Jun Ren, Congying Chen, Junwu Ma, Lusheng Huang.(2013) Genome-wide association mapping reveals genetic architecture of meat quality traits in Chinese Laiwu pigs. Mammalian Genome, 32(1): 139-154. (IF2013=2.883;生物III区).
1. Junwu Ma,Jie Yang,Lisheng Zhou,Zhiyan Zhang,Huanban Ma,Xianhua Xie,Feng Zhang,Xinwei Xiong,Leilei Cui,Hui Yang,Xianxian Liu,Yanyu Duan,Shijun Xiao,Huashui Ai,Jun Ren,Lusheng Huang.(2013) Genome-wide association study of meat quality traits in a White Duroc × Erhualian F2 intercross and Chinese Sutai pigs. PLoS One 8, e64047. (IF2013=3.534;生物III区).
科研创新
累计申请国家发明专利19项,其中15项获得国家发明专利授权。
教学活动
以教书育人为重要的人生目标,主要从事《养猪学》、《家畜育种学》的教学工作。
指导学生情况
鼓励培养学生们的独立思考能力,尽最大可能引导学生们热爱生活、爱上畜牧学科。先后协助指导博士研究生3名,作为第一和第二导师培养硕士研究生9名、本科生10名。
我的团队
我所在的团队—国家生猪种业工程技术研究中心(以下简称“中心”),是依托于华南农业大学和广东温氏食品集团股份有限公司组建的国家级研究开发平台,2013年4月获科技部立项,2017年9月顺利通过验收。“中心”长期致力于种猪分子遗传改良及专门化品系培育工作,近年来,课题组共承担农业部转基因重大专项和科技部“863”等国家级和省级项目87项;先后主持获得了国家科技进步二等奖1项、广东省科学技术奖一等奖2项、广东省农业技术推广奖一等奖2项、全国农牧渔业丰收奖农业技术推广合作奖1项、大北农科技奖一等奖1项和中国产学研合作成果一等奖1项等;另有“华农温氏I号猪”、“温氏WS501猪”2个通过国家畜禽新品种(配套系)审定的配套系。实验室现有使用面积1500平方米,现有猪遗传育种方向科研人员包括吴珍芳教授、蔡更元研究员、李紫聪教授、杨化强副研究员、杨杰副研究员、洪林君副教授、顾婷讲师、郑恩琴高级实验师、徐铮实验师、黄思秀助理研究员。“中心”拥有完善的动物遗传学、分子生物学和基因组学研究设备,仪器设备价值1600 余万元。另有1个国家核心育种场、2个省级原种场及1个科研猪场作为育种基地,科研环境良好。