目录
更新日期:2019年10月24日
姓 名 束刚 性 别
出生年月 1979年10月 籍贯 安徽庐江
民 族 汉族 政治面貌 中共党员
最后学历 博士研究生 最后学位 农学博士学位
技术职称 教授 导师类别 博、硕导
行政职务 系主任 Email shugang@scau.edu.cn
工作单位 动物营养与饲料科学系 邮政编码 510642
通讯地址
单位电话
个人主页
个人简介
束刚,男,1979年出生,华南农业大学动物科学学院教授,博士,动物营养与饲料科学系主任。畜牧兽医学会动物生理生化分会和广东省生理学会理事。2003年7月至今任教于华南农业大学动物科学学院,主要从事动物营养生理的教学与科研工作,2014年入选广东省优秀青年教师培养计划,2014-2015年在美国贝勒医学院儿童营养中心访问学者;2017年入选华南农业大学 “丁颖人才支持工程”;教育厅猪肉品质营养调控创新团队负责人;获广东省生理学会优秀中青年人才奖(2018年)和2019动物营养与饲料科学“颐和”青年创新奖。目前研究方向包括:(1)营养素代谢的感应机制;(2)营养素摄取和利用的代谢调控。本人先后主持国家自然科学基金3项,广东省重点领域研发计划项目1项,广东省自然科学基金1项和省部产学研及企业横向课题各1项;973和十三五重点研发骨干各3项;参加国家自然科学基金3项、广东省自然科学基金团队项目和国家“973”子项目等多项国家和省部级项目。在EMBO R (2019), Cell reports (2016, 2017), Metabolism (2018), FASEB Journal (2018), Journal of Nutritional Biochemistry (2014), journal of agriculture and food chemistry, Journal of Animal Science等杂志发表SCI论文40余篇,参编教材2部,参译1部,申报国家发明专利8项。
工作经历
2003.7 至今 华南农业大学动物科学学院
教育经历
1996 安徽科技学院 畜牧专业 本科
2000 南京农业大学 动物生理生化专业 硕士
2006 华南农业大学 动物营养与饲料科学 博士
2014 美国贝勒医学院儿童营养研究中心 访问学者
获奖、荣誉称号
2014 广东省优青培养对象
2017华南农业大学 “丁颖人才支持工程”
2018广东省生理学会优秀中青年人才奖
2019动物营养与饲料科学“颐和”青年创新奖。
社会、学会及学术兼职
畜牧兽医学会动物生理生化分会 理事 广东省生理学会 理事
研究领域
(1)营养素代谢中间产物的感应;(2)运动替代营养;(3)微生物发酵饲料。
科研项目
1. 广东省重点领域研发计划项目-微生物发酵饲料关键技术研究与应用(2019B020218001),(2018.9.1-2021.8.31)
2. 海外及港澳学者合作研究基金-糖胺聚糖提高动物饲料利用效率的机制(31828010),(2019.1-2020.12)
3. 十三五重点研发-日粮组成与饲养体制对畜禽健康优质肉形成的调控及机制——课题名称“肌纤维类型的形成规律与营养对其组成的调控”(2018YFD0500403),(2018.6-2020.12)
4. 十三五重点研发-畜禽营养代谢与中毒性疾病防控技术研究——课题名称:禽碳水化合物、蛋白质与能量代谢失衡防控技术研究(2016YFD0501205)(2016.7-2020.12)
5. 教育厅猪肉品质营养调控创新团队项目(2017KCXTD002),(2018.1-2020.12)
6. 广东省高等学校优秀青年教师培养项目 (2015年-2017年)。
7. 国家自然科学基金面上项目(31572480),猪下丘脑TLR4炎症通路在食欲调节中的作用及其分子机制,2016.01-2019.12,在研,主持。
8. 国家重点基础研究发展计划(973计划)课题(2013CB127306)、猪利用氮营养素的机制及营养调控。2013/01-2017/12、在研、课题骨干。
9. 广东省教育部产学研结合项目(2011B090400190),生产优质安全猪肉的饲料配制技术研究与推广应用、2011/03-2013/03、已结题、主持。
10. 国家自然科学基金(30972157)、猪FAT特异性调控肌内脂肪沉积的分子机制、2010/1-2012/12、已结题、主持。
11. 国家自然科学青年基金(30500367)、鸡脂肪酸转运蛋白(FATP1)参与体脂分配的分子机制研究、2006/1-2008/12、主持。
发表论文
Wang T, Xu YQ, Yuan YX, Xu PW, Zhang C, Li F, Wang LN, Yin C, Zhang L, Cai XC, Zhu CJ, Xu JR, Liang BQ, Schaul S, Xie PP, Yue D, Liao ZR, Yu LL, Luo L, Zhou G, Yang JP, He ZH, Du M, Zhou YP, Deng BC, Wang SB, Gao P, Zhu XT, Xi QY, Zhang YL, Shu G (corresponding author), Jiang QY. Succinate induces skeletal muscle fiber remodeling via SUNCR1 signaling pathway. EMBO Rep. 2019 Jul 18:e47892. doi: 10.15252/embr.201947892.
Cai X, Yuan Y, Liao Z, Xing K, Zhu C, Xu Y, Yu L, Wang L, Wang S, Zhu X, Gao P, Zhang Y, Jiang Q, Xu P, Shu G  (corresponding author). α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway. FASEB J. 2018 Jan;32(1):488-499. doi: 10.1096/fj.201700670R.(IF2016=5.5)
Jingren Xu, Canjun Zhu, Mengyuan Zhang, Qingchun Tong, Xiaojuan Wan, Zhengrui Liao, Xingcai Cai, Yaqiong Xu, Yexian Yuan, Lina Wang, Xiaotong Zhu, Songbo Wang, Ping Gao, Qianyun Xi, Yong Xu, Qingyan Jiang* and Gang Shu (corresponding author). Arginine Reverses Growth Hormone Resistance through the Inhibition of Toll-like Receptor 4-Mediated Inflammatory Pathway. Metabolism 2018 Feb;79:10-23. doi: 10.1016/j.metabol.2017.10.006(IF2016=5.78)
Yuan Y, Xu Y, Xu J, Liang B, Cai X, Zhu C, Wang L, Wang S, Zhu X, Gao P, Wang X, Zhang Y, Jiang Q, Shu G (corresponding author). Succinate promotes skeletal muscle protein synthesis via Erk1/2 signaling pathway. Mol Med Rep. 2017 Sep 20. doi: 10.3892/mmr.2017.7554.
Canjun Zhu1, 4, Pingwen Xu2, 4, Yanlin He2, 4, Yexian Yuan1, Tao Wang1, Xingcai Cai1, Lulu Yu1, Liusong Yang1, Junguo Wu1, Lina Wang1, Xiaotong Zhu1, Songbo Wang1, Ping Gao1, Qianyun Xi1, Yongliang Zhang1, Yong Xu2,3,*, Qingyan Jiang1, * and Gang Shu1, * (corresponding author). Heparin increases food intake through AgRP neurons.  Cell Rep. 2017, Sep 5; 20(10), p2455–2467.  (IF2016=8.28)
He Y#, Shu G# (co-first author), Yang Y, Xu P, Xia Y, Wang C, Saito K, Hinton A Jr, Yan X, Liu C, Wu Q, Tong Q, Xu Y. A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism. Cell Rep. 2016 Nov 8;17(7):1807-1818. (IF2016=8.28)
Liusong Yang1,*, Lina Wang1,*, Canjun Zhu1, Junguo Wu1, Yexian Yuan1, Lulu Yu1, Yaqiong Xu1, Jingren Xu1, Tao Wang1, Zhengrui Liao1, Songbo Wang1,3, Xiaotong Zhu1, Ping Gao1, Yongliang Zhang1,2, Xiuqi Wang2,3, Qingyan Jiang1,3 and Gang Shu1,2,3 (corresponding author). Laminarin counteracts diet-induced obesity associated with glucagon-like peptide-1 secretion. 2017. https://doi.org/10.18632/oncotarget.19957. (IF2016=5.17)
Wu J, Zhu C, Yang L, Wang Z, Wang L, Wang S, Gao P, Zhang Y, Jiang Q, Zhu X, Shu G (corresponding author). N-Oleoylglycine-Induced Hyperphagia Is Associated with the Activation of Agouti-Related Protein (AgRP) Neuron by Cannabinoid Receptor Type 1 (CB1R). J Agric Food Chem. 2017 Feb 8;65(5):1051-1057. (IF2016=3.15)
Wang S, Wang G, Zhang M, Zhuang L, Wan X, Xu J, Wang L, Zhu X, Gao P, Xi Q, Zhang Y, Shu G (co-correspondings author), Jiang Q*. The dipeptide Pro-Asp promotes IGF-1 secretion and expression in hepatocytes by enhancing JAK2/STAT5 signaling pathway.Mol Cell Endocrinol. 2016 Nov 15;436:204-10. (IF2016=3.75)
Cai X, Zhu C, Xu Y, Jing Y, Yuan Y, Wang L, Wang S, Zhu X, Gao P, Zhang Y, Jiang Q, Shu G (corresponding author). Alpha-ketoglutarate promotes skeletal muscle hypertrophy and protein synthesis through Akt/mTOR signaling pathways. Sci Rep. 2016 May 26;6:26802. (IF2016=4.26)
Jing Y, Cai X, Xu Y, Zhu C, Wang L, Wang S, Zhu X, Gao P, Zhang Y, Jiang Q, Shu G (corresponding author).α-Lipoic Acids Promote the Protein Synthesis of C2C12 Myotubes by the TLR2/PI3K Signaling Pathway. J Agric Food Chem. 2016 Mar 2;64(8):1720-9. (IF2016=3.15)
Wang S, Xiang N, Yang L, Zhu C, Zhu X, Wang L, Gao P, Xi Q, Zhang Y, Shu G (co-corresponding author), Jiang Q. Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. Biochem Biophys Res Commun. 2016 Mar 18;471(4):566-71.
Yan C, He Y, Xu Y, Shu G, Wang C, Yang Y, Saito K, Xu P, Hinton AO Jr, Yan X, Yu L, Wu Q, Tso P, Tong Q, Xu Y. Apolipoprotein A-IV Inhibits AgRP/NPY Neurons and Activates POMC Neurons in the Arcuate Nucleus. Neuroendocrinology. 2015 Aug 25.
Gang Shu, Lu NS, Zhu XT, Xu Y, Du MQ, Xie QP, Zhu CJ, Xu Q, Wang SB, Wang LN, Gao P, Xi QY, Zhang YL, Jiang QY. Phloretin promotes adipocyte differentiation in vitro and improves glucose homeostasis in vivo. Journal of Nutritional Biochemistry. 2014 Dec;25(12):1296-308.
Gang Shu*,1, Xing-Ling Fang, Sheng-Feng Chen*, Zhi-Qi Zhang*, Qing-Jie Zeng*, Lin Deng*, Jian-Long Peng*, Jian-Jian Yu*, Li-Na Wang*, Xiao-Tong Zhu*, Song-Bo Wang*, Ping Gao*, and Qing-yan Jiang. Differential gene expression pattern in hypothalamus of chickens during fasting-induced metabolic reprogramming: functions of glucose and lipid metabolism in the feed intake of chickens. Poultry Science. 2014 Nov;93(11):2841-54.
Zhang ZQ, Shu G, Zhu XT, Wang LN, Fu Q, Hou LJ, Wang SB, Gao P, Xi QY, Zhang YL, Yu L, Lv JR, Jiang QY. Isolation and characterization of porcine circumvallate papillae cells. Acta Histochem. 2014 Oct;116(8):1313-22.
Zhiqi Zhang1,† Gang Shu1,†(co-first author) Xiaotong Zhu1, Junming Guo1, Han Cai1, Songbo Wang1, Lina Wang1, Ping Gao1, Qianyun Xi1, Yongliang Zhang1, Li Yuan2, Qingyan Jiang1.* Effect of diacylglycerol acyltransferase 2 overexpression in 3T3-L1 is associated to an increase in mono-unsaturated fatty acid accumulation. Journal of Animal Science and Biotechnology. 2014 May 28;5(1):29.
Xing-Ling Fang*, Gang Shu* (co-first author), Jian-Jian Yu*, Li-Na Wang, Jing Yang, Qing-Jie Zeng, Xiao Cheng, Zhi-Qi Zhang, Song-Bo Wang, Ping Gao, Xiao-Tong Zhu, Qian-Yu Xi, Yong-Liang Zhang, Qing-Yan Jiang§. The anorexigenic effect of serotonin is mediated by the generation of NADPH Oxidase-Dependent ROS. PLoS One. 2013;8(1):e53142. doi: 10.1371/journal.pone.0053142.
Songbo Wang, Guixuan Zhou, Gang Shu, Lina Wang, Xiaotong Zhu, Ping Gao, Qianyun Xi,  Yongliang Zhang, Li Yuan, Qingyan Jiang. Glucose Utilization, Lipid Metabolism and BMP-Smad Signaling Pathway of Porcine Intramuscular Preadipocytes Compared with Subcutaneous Preadipocytes. Cellular Physiology and Biochemistry, 2013, 31:981-996.
"Kaifan Yu*1, Gang Shu*1 (co-first author), Fangfang yuan1, Xiaotong Zhu1, Ping Gao1, Songbo Wang1, Lina Wang1, QianyunXi1, Shouquan Zhang1, Yongliang Zhang1, Yan Li2, Tongshan Wu2, Li Yuan3,Qingyan Jiang1",Fatty Acid and Transcriptome Profiling of Longissimus Dorsi Muscles between Pig Breeds Differing in Meat Quality, International Journal of Biological Sciences, 2013, 1449-2288, 9(1):108-118.
Junming Guo1*, Gang Shu1* (co-first author), Lihua Zhou1*, Xiaotong Zhu1, Weiyi Liao1, Songbo Wang1, Jinzeng Yang3, Guixuan Zhou1, Qianyun Xi1, Ping Gao1, Yongliang Zhang1, Shouquan Zhang1, Li Yuan2, and Qingyan Jiang1. Selective Transport of Long Chain Fatty Acids by FAT/CD36 in Skeletal Muscle of Broilers. Animal. 2012.DOI: 10.1017/S1751731112001619.
Xing-Ling Fang*, Gang Shu* (co-first author), Jian-Jian Yu*, Li-Na Wang, Jing Yang, Qing-Jie Zeng, Xiao Cheng, Zhi-Qi Zhang, Song-Bo Wang, Ping Gao, Xiao-Tong Zhu, Qian-Yu Xi, Yong-Liang Zhang, Qing-Yan Jiang§. The anorexigenic effect of serotonin is mediated by the generation of NADPH Oxidase-Dependent ROS. PLoS One. 2013;8(1):e53142. doi: 10.1371/journal.pone.0053142. Epub 2013 Jan 9.
Songbo Wang  Guixuan Zhou  Gang Shu  Lina Wang  Xiaotong Zhu Ping Gao Qianyun Xi  Yongliang Zhang  Li Yuan  Qingyan Jiang, Glucose Utilization, Lipid Metabolism and BMP-Smad Signaling Pathway of Porcine Intramuscular Preadipocytes Compared with Subcutaneous Preadipocytes, Cellular Physiology and Biochemistry, 1015-8987, 31:981-996, 2013
"Kaifan Yu*1, Gang Shu*1, Fangfang yuan1, Xiaotong Zhu1, Ping Gao1, Songbo Wang1, Lina Wang1, QianyunXi1, Shouquan Zhang1, Yongliang Zhang1, Yan Li2, Tongshan Wu2, Li Yuan3,Qingyan Jiang1",Fatty Acid and Transcriptome Profiling of Longissimus Dorsi Muscles between Pig Breeds Differing in Meat Quality, International Journal of Biological Sciences, 1449-2288, 9(1):108-118,2013
Ya-Feng Z, Gang S, Xiao-Tong Z, Zhi-Qi Z, Xia-Jing L, Song-Bo W, Li-Na W, Yong-Liang Z, Qing-Yan J, Identification of an intestine-specific promoter and inducible expression of bacterial alpha-galactosidase in mammalian cells by a lac operon system, Journal of Animal Science and Biotechnology,2049-189, 3(1):32,2012
Shu, G., W. Y. Liao, J. Y. Feng, K. F. Yu, Y. F. Zhai, S. B. Wang, P. Khondowe, X. Q. Wang & Q. Y. Jiang (2011) Active immunization of fatty acid translocase specifically decreased visceral fat deposition in male broilers. Poultry Science, 90, 2557-2564.
Xin-Ling Fang, Gang Shu (co-first author),, Zhi-Qi Zhang,Song-Bo Wang, Xiao-Tong Zhu, Ping Gao, Qian-Yun Xi, Yong-Liang Zhang & Qing-Yan Jiang. Roles of α-linolenic acid on IGF-I secretion and GH/IGF system gene expression in porcine primary hepatocytes. Molecular Biology Reports. 2012.39:10987–10996.
Shu, G., X. T. Zhu, X. Q. Wang, Y. Z. Song, Y. F. Bin, Y. L. Zhang, P. Gao & Q. Y. Jiang (2009) Identification and gene expression of porcine fatty acid transport protein 1 isoforms. Journal of Animal Physiology and Animal Nutrition, 93, 439-446.
Luo, Z. F., X. L. Fang, G. Shu (co-first author), S. B. Wang, X. T. Zhu, P. Gao, L. L. Chen, C. Y. Chen, Q. Y. Xi, Y. L. Zhang & Q. Y. Jiang (2011) Sorbic acid improves growth performance and regulates insulin-like growth factor system gene expression in swine. Journal of Animal Science, 89, 2356-2364.
Shu, G., Q. Y. Jiang, X. T. Zhu, H. X. Zhang, P. Gao, Y. L. Zhang & X. Q. Wang (2008) Identification of porcine fatty acid translocase: high-level transcript in intramuscular fat. Journal of Animal Physiology and Animal Nutrition, 92, 562-568.
Shu, G., P. Gao, X. T. Zhu, Q. Y. Jiang, P. W. Xu, G. X. Zhou, F. W. Sun & W. L. Fu (2007) Effects of glycyl-glutamine on the growth performance and lipid deposition in Yue-Huang broilers. Journal of Animal and Feed Sciences, 16, 232-240.
Tang, S.-Q., S. Gang, X.-T. Zhu, S.-B. Wang, G. Ping, X.-Q. Wang, Y.-L. Zhang & Q.-Y. Jiang (2009) Effects of pGhrelin on Caspase-3 Activity and Gene Expression of Porcine Predipocytes in Culture. Progress in Biochemistry and Biophysics, 36, 897-903.
Xu, P.-w., X.-l. Fang, G. Shu, X.-t. Zhu, Z.-f. Luo, Q.-y. Jiang, P. Gao & Y.-l. Zhang (2010) Prokaryotic Expression of Gly-Gln Dipeptide and Its Bioactive Analysis: A Novel Method for Short Peptide Production. Agricultural Sciences in China, 9, 736-744.
Wang, X.-q., Y. Feng, G. Shu, Q.-y. Jiang, J.-p. Yang & Z.-f. Zhang (2011) Effect of Dietary Supplementation with Hydrolyzed Wheat Gluten on Growth Performance, Cell Immunity and Serum Biochemical Indices of Weaned Piglets (Sus scrofa). Agricultural Sciences in China, 10, 938-945.
Zhou, G., S. Wang, Z. Wang, X. Zhu, G. Shu, W. Liao, K. Yu, P. Gao, Q. Xi, X. Wang, Y. Zhang, L. Yuan & Q. Jiang (2010) Global comparison of gene expression profiles between intramuscular and subcutaneous adipocytes of neonatal landrace pig using microarray. Meat Science, 86, 440-450.
Li, H., Q. Xi, Y. Xiong, X. Cheng, Q. Qi, L. Yang, G. Shu, S. Wang, L. Wang, P. Gao, X. Zhu, Q. Jiang, Y. Zhang & L. Yuan (2011)  A Comprehensive Expression Profile of MicroRNAs in Porcine Pituitary. PloS one, 6.
束 刚*,冯嘉颖*,余凯凡,徐平稳,朱晓彤,高  萍,王松波,习欠云,王修启,张永亮,江青艳。FAT/CD36融合蛋白的表达及其对腹脂沉积的特异性调控。中国农业科学 2009,42(2)
林厦菁,朱晓彤,江青艳,束刚, 叶绿醇对脂肪细胞分化及糖脂代谢的调节作用, 动物营养学, 24(10): 1866-1870,2012
张志歧,束刚,江青艳, 下丘脑对脂类的营养感应及其对食欲的影响, 动物营养学报中国, 25(7) :1395-1405,2013
科研创新
江青艳、束刚等,《已二稀酸在制备改善猪肉品质的饲料添加剂方面的应用》,2010.5,中国,20100510442.2
束刚、江青艳等,《叶绿醇在制备猪饲料添加剂方面的应用及猪饲料》,2013.6,中国,201310249144.6
束刚、江青艳等,《酮戊二酸在制备猪饲料添加剂方面的应用》,2015.9,中国201510610185.2